Publication:
Ferroptosis and kidney disease

dc.contributor.authorMartin-Sanchez, Diego
dc.contributor.authorFontecha-Barriuso, Miguel
dc.contributor.authorMartinez-Moreno, Julio M.
dc.contributor.authorRamos, Adrian M.
dc.contributor.authorSanchez-Niño, Maria D.
dc.contributor.authorGuerrero-Hue, Melania
dc.contributor.authorMoreno, Juan A.
dc.contributor.authorOrtiz, Alberto
dc.contributor.authorSanz, Ana B.
dc.contributor.authoraffiliation[Martin-Sanchez,D; Fontecha-Barriuso,M; Martinez-Moreno,JM; Ramos,AM; Sanchez-Niño,MD; Ortiz,A; Sanz,AB] Research Institute-Fundacion Jimenez Diaz, Autonoma University, Madrid, Spain. [Martin-Sanchez,D; Fontecha-Barriuso,M; Martinez-Moreno,JM; Ramos,AM; Sanchez-Niño,MD; Ortiz,A; Sanz,AB] REDINREN, Madrid, Spain. [Ortiz,A] School of Medicine, UAM, Madrid, Spain. [Guerrero-Hue,M; Moreno,JA] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain. [Moreno,JA] Department of Cell Biology, Physiology and Immunology, University of Cordoba, Spain. [Moreno,JA] Hospital Universitario Reina Sofia, Cordoba, Spain. [Moreno,JA] Centre of Biomedical Research in Network of Cardiovascular Disease (CIBERCV), Madrid, Spain.
dc.contributor.funderFIS/Fondos FEDER (PI15/00298, CP14/00133, PI16/02057, PI16/01900, PI18/01366), ISCIII-RETIC REDinREN RD016/0009, ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18/00064 and PERSTIGAN AC18/00071), DTS18/00032, Sociedad Española de Nefrología, FRIAT, Comunidad de Madrid en Biomedicina B2017/BMD-3686 CIFRA2-CM.
dc.date.accessioned2022-03-21T11:02:52Z
dc.date.available2022-03-21T11:02:52Z
dc.date.issued2020
dc.description.abstractLa muerte celular es un proceso minuciosamente regulado que se desarrolla a través de diferentes vías. La muerte celular regulada, ya sea mediante apoptosis o necrosis regulada, ofrece la posibilidad de introducir una intervención terapéutica. La necroptosis y la ferroptosis se encuentran entre las formas mejor estudiadas de necrosis regulada en el contexto de la nefropatía. Revisamos los datos actuales que avalan que la ferroptosis desempeña una función en la nefropatía y las repercusiones que tiene este conocimiento en el diseño de nuevas estrategias terapéuticas. La ferroptosis se define de forma funcional como una modalidad celular caracterizada por la peroxidación de ciertos lípidos, constitutivamente suprimida por GPX4 e inhibida por quelantes férricos y antioxidantes lipofílicos. Existen datos probatorios funcionales de la implicación de la ferroptosis en diversas formas de nefropatía. En un modelo de lesión renal aguda nefrotóxica bien caracterizado, la ferroptosis provocó una ola inicial de muerte, la cual desencadenó una respuesta inflamatoria que a su vez promovió la muerte celular necroptótica que perpetuó la disfunción renal. Esto sugiere que los inhibidores de la ferroptosis pueden explorarse como agentes profilácticos en la nefrotoxicidad clínica o en la lesión por isquemia-reperfusión, como durante un trasplante de riñón. Los trasplantes ofrecen una oportunidad única para el uso de agentes inhibidores de la ferroptosis ex vivo, con lo que se evitarían los problemas de biodisponibilidad y los problemas de farmacocinética y farmacodinámica in vivo.es_ES
dc.description.abstractCell death is a finely regulated process occurring through different pathways. Regulated cell death, either through apoptosis or regulated necrosis offers the possibility of therapeutic intervention. Necroptosis and ferroptosis are among the best studied forms of regulated necrosis in the context of kidney disease. We now review the current evidence supporting a role for ferroptosis in kidney disease and the implications of this knowledge for the design of novel therapeutic strategies. Ferroptosis is defined functionally, as a cell modality characterized by peroxidation of certain lipids, constitutively suppressed by GPX4 and inhibited by iron chelators and lipophilic antioxidants. There is functional evidence of the involvement of ferroptosis in diverse forms of kidneys disease. In a well characterized nephrotoxic acute kidney injury model, ferroptosis caused an initial wave of death, triggering an inflammatory response that in turn promoted necroptotic cell death that perpetuated kidney dysfunction. This suggests that ferroptosis inhibitors may be explored as prophylactic agents in clinical nephrotoxicity or ischemia-reperfusion injury such as during kidney transplantation. Transplantation offers the unique opportunity of using anti-ferroptosis agent ex vivo, thus avoiding bioavailability and in vivo pharmacokinetics and pharmacodynamics issues.es_ES
dc.description.versionYeses_ES
dc.identifier.citationMartin-Sanchez D, Fontecha-Barriuso M, Martinez-Moreno JM, Ramos AM, Sanchez-Niño MD, Guerrero-Hue M, et al. Ferroptosis and kidney disease. Nefrologia (Engl Ed). 2020 Jul-Aug;40(4):384-394.es_ES
dc.identifier.doi10.1016/j.nefro.2020.03.005es_ES
dc.identifier.essn2013-2514
dc.identifier.pmid32624210es_ES
dc.identifier.urihttp://hdl.handle.net/10668/3481
dc.journal.titleNefrologia (English Edition)
dc.language.isoen
dc.page.number11 p.
dc.publisherSociedad Española de Nefrología. Editor comercial: Elsevier España, S.L.U.es_ES
dc.relation.publisherversionhttps://www.revistanefrologia.com/es-ferroptosis-kidney-disease-articulo-S0211699520300527es_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAcute kidney injuryes_ES
dc.subjectChronic kidney diseasees_ES
dc.subjectInflammationes_ES
dc.subjectCell deathes_ES
dc.subjectRegulated necrosises_ES
dc.subjectFerroptosises_ES
dc.subjectLesión renal agudaes_ES
dc.subjectEnfermedad renal crónicaes_ES
dc.subjectInflamaciónes_ES
dc.subjectMuerte celulares_ES
dc.subjectNecrosis reguladaes_ES
dc.subjectApoptosises_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Diseases::Male Urogenital Diseases::Urologic Diseases::Kidney Diseaseses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosises_ES
dc.subject.meshMedical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Urologic Diseases::Kidney Diseaseses_ES
dc.subject.meshMedical Subject Headings::Diseases::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Acute Kidney Injuryes_ES
dc.subject.meshMedical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Acute Kidney Injuryes_ES
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammationes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Deathes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Necrosises_ES
dc.titleFerroptosis and kidney diseasees_ES
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication
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