Publication: Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis.
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Identifiers
Date
2020-10-13
Authors
Saberi Hosnijeh, Fatemeh
Casabonne, Delphine
Nieters, Alexandra
Solans, Marta
Naudin, Sabine
Ferrari, Pietro
Mckay, James D
Benavente, Yolanda
Weiderpass, Elisabete
Freisling, Heinz
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley & Sons, Inc.
Abstract
To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL.
Description
MeSH Terms
Anthropometry
Cohort Studies
Exposome
Female
Humans
Life Style
Lymphoma, B-Cell
Male
Middle Aged
Prospective Studies
Risk Factors
Cohort Studies
Exposome
Female
Humans
Life Style
Lymphoma, B-Cell
Male
Middle Aged
Prospective Studies
Risk Factors
DeCS Terms
Antropometría
Estilo de vida
Estudios prospectivos
Estudios de cohortes
Exposoma
Factores de riesgo
Femenino
Humanos
Linfoma de células B
Masculino
Persona de mediana edad
Estilo de vida
Estudios prospectivos
Estudios de cohortes
Exposoma
Factores de riesgo
Femenino
Humanos
Linfoma de células B
Masculino
Persona de mediana edad
CIE Terms
Keywords
exposome, exposome-wide association study, lifestyle, lymphoma, prospective study
Citation
Saberi Hosnijeh F, Casabonne D, Nieters A, Solans M, Naudin S, Ferrari P, et al. Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis. Int J Cancer. 2021 May 1;148(9):2115-2128.