RT Journal Article
T1 Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis.
A1 Saberi Hosnijeh, Fatemeh
A1 Casabonne, Delphine
A1 Nieters, Alexandra
A1 Solans, Marta
A1 Naudin, Sabine
A1 Ferrari, Pietro
A1 Mckay, James D
A1 Benavente, Yolanda
A1 Weiderpass, Elisabete
A1 Freisling, Heinz
A1 Severi, Gianluca
A1 Boutron Ruault, Marie-Christine
A1 Besson, Caroline
A1 Agnoli, Claudia
A1 Masala, Giovanna
A1 Sacerdote, Carlotta
A1 Tumino, Rosario
A1 Huerta, Jose Maria
A1 Amiano, Pilar
A1 Rodriguez-Barranco, Miguel
A1 Bonet, Catalina
A1 Barricarte, Aurelio
A1 Christakoudi, Sofia
A1 Knuppel, Anika
A1 Bueno-de-Mesquita, Bas
A1 Schulze, Matthias B
A1 Kaaks, Rudolf
A1 Canzian, Federico
A1 Späth, Florentin
A1 Jerkeman, Mats
A1 Rylander, Charlotta
A1 Tjønneland, Anne
A1 Olsen, Anja
A1 Borch, Kristin Benjaminsen
A1 Vermeulen, Roel
K1 exposome
K1 exposome-wide association study
K1 lifestyle
K1 lymphoma
K1 prospective study
AB To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL.
PB John Wiley & Sons, Inc.
YR 2020
FD 2020-10-13
LK http://hdl.handle.net/10668/16510
UL http://hdl.handle.net/10668/16510
LA en
NO Saberi Hosnijeh F, Casabonne D, Nieters A, Solans M, Naudin S, Ferrari P, et al. Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis. Int J Cancer. 2021 May 1;148(9):2115-2128.
DS RISalud
RD Apr 14, 2025