Publication:
Toxoplasma gondii Seropositivity Interacts with Catechol-O-methyltransferase Val105/158Met Variation Increasing the Risk of Schizophrenia.

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Date

2022-06-16

Authors

Rovira, Paula
Gutierrez, Blanca
Sorlozano-Puerto, Antonio
Gutierrez-Fernandez, Jose
Molina, Esther
Rivera, Margarita
Martinez-Leal, Rafael
Ibanez-Casas, Inmaculada
Martin-Laguna, María Victoria
Rosa, Araceli

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MDPI AG
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Abstract

Schizophrenia is a heterogeneous and severe psychotic disorder. Epidemiological findings have suggested that the exposure to infectious agents such as Toxoplasma gondii (T. gondii) is associated with an increased risk for schizophrenia. On the other hand, there is evidence involving the catechol-O-methyltransferase (COMT) Val105/158Met polymorphism in the aetiology of schizophrenia since it alters the dopamine metabolism. A case−control study of 141 patients and 142 controls was conducted to analyse the polymorphism, the prevalence of anti-T. gondii IgG, and their interaction on the risk for schizophrenia. IgG were detected by ELISA, and genotyping was performed with TaqMan Real-Time PCR. Although no association was found between any COMT genotype and schizophrenia, we found a significant association between T. gondii seropositivity and the disorder (χ2 = 11.71; p-value

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MeSH Terms

Case-Control Studies
Catechol O-Methyltransferase
Humans
Immunoglobulin G
Schizophrenia
Toxoplasma
Toxoplasmosis

DeCS Terms

Catecol O-Metiltransferasa
Esquizofrenia
Estudios de casos y controles
Humanos
Inmunoglobulina G
Toxoplasma
Toxoplasmosis

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Keywords

COMT, Toxoplasma gondii, case–control study, gene–environment interaction, infectious agents, schizophrenia

Citation

Rovira P, Gutiérrez B, Sorlózano-Puerto A, Gutiérrez-Fernández J, Molina E, Rivera M, et al. Toxoplasma gondii Seropositivity Interacts with Catechol-O-methyltransferase Val105/158Met Variation Increasing the Risk of Schizophrenia. Genes (Basel). 2022 Jun 18;13(6):1088.