RT Journal Article
T1 Toxoplasma gondii Seropositivity Interacts with Catechol-O-methyltransferase Val105/158Met Variation Increasing the Risk of Schizophrenia.
A1 Rovira, Paula
A1 Gutierrez, Blanca
A1 Sorlozano-Puerto, Antonio
A1 Gutierrez-Fernandez, Jose
A1 Molina, Esther
A1 Rivera, Margarita
A1 Martinez-Leal, Rafael
A1 Ibanez-Casas, Inmaculada
A1 Martin-Laguna, María Victoria
A1 Rosa, Araceli
A1 Torres-Gonzalez, Francisco
A1 Cervilla, Jorge A
K1 COMT
K1 Toxoplasma gondii
K1 case–control study
K1 gene–environment interaction
K1 infectious agents
K1 schizophrenia
AB Schizophrenia is a heterogeneous and severe psychotic disorder. Epidemiological findings have suggested that the exposure to infectious agents such as Toxoplasma gondii (T. gondii) is associated with an increased risk for schizophrenia. On the other hand, there is evidence involving the catechol-O-methyltransferase (COMT) Val105/158Met polymorphism in the aetiology of schizophrenia since it alters the dopamine metabolism. A case−control study of 141 patients and 142 controls was conducted to analyse the polymorphism, the prevalence of anti-T. gondii IgG, and their interaction on the risk for schizophrenia. IgG were detected by ELISA, and genotyping was performed with TaqMan Real-Time PCR. Although no association was found between any COMT genotype and schizophrenia, we found a significant association between T. gondii seropositivity and the disorder (χ2 = 11.71; p-value
PB MDPI AG
YR 2022
FD 2022-06-16
LK http://hdl.handle.net/10668/20980
UL http://hdl.handle.net/10668/20980
LA en
NO Rovira P, Gutiérrez B, Sorlózano-Puerto A, Gutiérrez-Fernández J, Molina E, Rivera M, et al. Toxoplasma gondii Seropositivity Interacts with Catechol-O-methyltransferase Val105/158Met Variation Increasing the Risk of Schizophrenia. Genes (Basel). 2022 Jun 18;13(6):1088.
DS RISalud
RD Apr 18, 2025