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Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers: A retrospective nested case-control study in two prospective cohorts.

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dc.contributor.authorWu, Wendy Yi-Ying
dc.contributor.authorHaider, Zahra
dc.contributor.authorFeng, Xiaoshuang
dc.contributor.authorHeath, Alicia K
dc.contributor.authorTjønneland, Anne
dc.contributor.authorAgudo, Antonio
dc.contributor.authorMasala, Giovanna
dc.contributor.authorRobbins, Hilary A
dc.contributor.authorHuerta, Jose-Maria
dc.contributor.authorGuevara, Marcela
dc.contributor.authorSchulze, Matthias B
dc.contributor.authorRodriguez-Barranco, Miguel
dc.contributor.authorVineis, Paolo
dc.contributor.authorTumino, Rosario
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorFortner, Renée T
dc.contributor.authorSieri, Sabina
dc.contributor.authorPanico, Salvatore
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorBraaten, Tonje
dc.contributor.authorJohansson, Mattias
dc.contributor.authorMelin, Beatrice
dc.contributor.authorJohansson, Mikael
dc.contributor.funderHealth Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII)
dc.contributor.funderWorld Cancer Research Fund (WCRF)
dc.contributor.funderInternational Agency for Research on Cancer (IARC)
dc.contributor.funderRegional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology - ICO (Spain)
dc.date.accessioned2023-05-03T14:52:08Z
dc.date.available2023-05-03T14:52:08Z
dc.date.issued2022-10-05
dc.description.abstractThe EarlyCDT-Lung test is a blood-based autoantibody assay intended to identify high-risk individuals for low-dose computed tomography lung cancer screening. However, there is a paucity of evidence on the performance of the EarlyCDT-Lung test in ever-smokers. We conducted a nested case-control study within two prospective cohorts to evaluate the risk-discriminatory performance of the EarlyCDT-Lung test using prediagnostic blood samples from 154 future lung cancer cases and 154 matched controls. Cases were selected from those who had ever smoked and had a prediagnostic blood sample
dc.description.sponsorshipOur study was supported by an early detection of cancer development grant from Swedish Department of Health Ministry. The participation of IARC personnel was supported by a programme award from the US National Cancer Institute (NCI U19 CA203654). Part of the study was supported by a generous grant from the Cancer Research Foundation of Northern Sweden (AMP19-962). We thank the Biobank Research Unit at Umeå Universitet, Västerbotten Intervention Programme, the Northern Sweden MONICA study, the Mammography Study and Region Västerbotten for providing data and samples and acknowledge the contribution from Biobank Sweden, supported by the Swedish Research Council (VR 2017-00650). The coordination of EPIC is financially supported by International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC). The national cohorts are supported by: Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); Deutsche Krebshilfe, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology - ICO (Spain); Cancerfonden, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford) (United Kingdom). In addition, we thank Kim Overvad from EPIC Aarhus, Demark, and the National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands, for their contribution and ongoing support to the EPIC Study.
dc.description.versionSi
dc.identifier.citationWu WY, Haider Z, Feng X, Heath AK, Tjønneland A, Agudo A, et al. Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers: A retrospective nested case-control study in two prospective cohorts. Int J Cancer. 2023 May 1;152(9):2002-2010.
dc.identifier.doi10.1002/ijc.34340
dc.identifier.essn1097-0215
dc.identifier.pmid36305647
dc.identifier.unpaywallURLhttps://doi.org/10.1002/ijc.34340
dc.identifier.urihttp://hdl.handle.net/10668/22117
dc.issue.number9
dc.journal.titleInternational journal of cancer
dc.journal.titleabbreviationInt J Cancer
dc.language.isoen
dc.organizationEscuela Andaluza de Salud Pública-EASP
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number2002-2010
dc.provenanceRealizada la curación de contenido 04/09/2024
dc.publisherJohn Wiley & Sons, Inc.
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.pubmedtypeResearch Support, N.I.H., Extramural
dc.relation.publisherversionhttps://doi.org/10.1002/ijc.34340
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectEarlyCDT-Lung test
dc.subjectbiomarkers
dc.subjectlung cancer
dc.subjectprediagnostic samples
dc.subject.decsBiomarcadores
dc.subject.decsDetección precoz del cáncer
dc.subject.decsEstudios prospectivos
dc.subject.decsEstudios retrospectivos
dc.subject.decsEstudios de casos y controles
dc.subject.decsFumadores
dc.subject.decsHumanos
dc.subject.decsNeoplasias pulmonares
dc.subject.decsPulmón
dc.subject.meshHumans
dc.subject.meshLung Neoplasms
dc.subject.meshCase-Control Studies
dc.subject.meshRetrospective Studies
dc.subject.meshEarly Detection of Cancer
dc.subject.meshSmokers
dc.subject.meshProspective Studies
dc.subject.meshBiomarkers
dc.subject.meshLung
dc.titleAssessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers: A retrospective nested case-control study in two prospective cohorts.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number152
dspace.entity.typePublication

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