Publication:
SEOM-GECOD clinical guideline for unknown primary cancer (2021).

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Date

2022-03-23

Authors

Losa, Ferran
Fernandez, Isaura
Etxaniz, Olatz
Gimenez, Alejandra
Gomila, Paula
Iglesias, Lara
Longo, Federico
Nogales, Esteban
Sanchez, Antonio
Soler, Gemma

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Springer
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Abstract

Cancer of unknown primary site (CUP) is defined as a heterogeneous group of tumors that appear as metastases, and of which standard diagnostic work-up fails to identify the origin. It is considered a separate entity with a specific biology, and nowadays molecular characteristics and the determination of actionable mutations may be important in a significant group of patients. In this guide, we summarize the diagnostic, therapeutic, and possible new developments in molecular medicine that may help us in the management of this unique disease entity.

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MeSH Terms

Humans
Neoplasms, Unknown Primary
Molecular Medicine
Gain of Function Mutation
Patients

DeCS Terms

Metástasis de la neoplasia
Neoplasias pulmonares
Inmunohistoquímica
Neoplasias cutáneas

CIE Terms

Keywords

Cancer, Diagnosis, Treatment, Unknown primary site

Citation

Losa F, Fernández I, Etxaniz O, Giménez A, Gomila P, Iglesias L, et al. SEOM-GECOD clinical guideline for unknown primary cancer (2021). Clin Transl Oncol. 2022 Apr;24(4):681-692