RT Journal Article T1 SEOM-GECOD clinical guideline for unknown primary cancer (2021). A1 Losa, Ferrán A1 Fernández, Isaura A1 Etxaniz, Olatz A1 Giménez, Alejandra A1 Gomila, Paula A1 Iglesias, Lara A1 Longo, Federico A1 Nogales, Esteban A1 Sánchez, Antonio A1 Soler, Gemma K1 Cancer K1 Diagnosis K1 Treatment K1 Unknown primary site AB Cancer of unknown primary site (CUP) is defined as a heterogeneous group of tumors that appear as metastases, and of which standard diagnostic work-up fails to identify the origin. It is considered a separate entity with a specific biology, and nowadays molecular characteristics and the determination of actionable mutations may be important in a significant group of patients. In this guide, we summarize the diagnostic, therapeutic, and possible new developments in molecular medicine that may help us in the management of this unique disease entity. YR 2022 FD 2022-03-23 LK http://hdl.handle.net/10668/21097 UL http://hdl.handle.net/10668/21097 LA en DS RISalud RD Apr 18, 2025