Publication:
Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study.

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Date

2018-09-21

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Gómez-Acebo, Inés
Dierssen-Sotos, Trinidad
de Pedro, María
Pérez-Gómez, Beatriz
Castaño-Vinyals, Gemma
Fernández-Villa, Tania
Palazuelos-Calderón, Camilo
Amiano, Pilar
Etxeberria, Jaione
Benavente, Yolanda

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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used despite their risk of gastrointestinal bleeding or cardiovascular events. We report the profile of people taking NSAIDs in Spain, and we include demographic factors, health-related behaviours and cardiovascular disease history. Four thousand sixtyparticipants were selected using a pseudorandom number list from Family Practice lists in 12 Spanish provinces. They completed a face-to-face computerized interview on their NSAID consumption, demographic characteristics, body mass index, alcohol and tobacco consumption and medical history. In addition, participants completed a self-administered food-frequency and alcohol consumption questionnaire. Factors associated with ever and current NSAID consumption were identified by logistic regression. Women consumed more non-aspirin NSAIDs (38.8% [36.7-41.0]) than men (22.3 [20.5-24.2]), but men consumed more aspirin (11.7% [10.3-13.2]) than women (5.2% [4.3-6.3]). Consumption of non-aspirin NSAIDs decrease with age from 44.2% (39.4-49.1) in younger than 45 to 21.1% (18.3-24.2) in older than 75, but the age-pattern for aspirin usage was the opposite. Aspirin was reported by about 11% patients, as being twice as used in men (11.7%) than in women (5.2%); its consumption increased with age from 1.7% ( Non-aspirin NSAIDs were more consumed by women and aspirin by men. The age patterns of aspirin and non-aspirin NSAIDs were opposite: the higher the age, the lower the non-aspirin NSAIDs usage and the higher the aspirin consumption. People with cardiovascular risk factors or diseases consumed more aspirin, but they did not decrease their non-aspirin NSAIDs usage.

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Adult
Age Distribution
Aged
Anti-Inflammatory Agents, Non-Steroidal
Aspirin
Cardiovascular Diseases
Case-Control Studies
Female
Gastrointestinal Hemorrhage
Humans
Male
Middle Aged
Risk Factors
Sex Distribution
Spain
Surveys and Questionnaires

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Keywords

Aspirin, Cardiovascular risk, Gastrointestinal bleeding, Non-steroidal anti-inflammatory drugs, Propionates

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