Publication:
TRPs in Pain Sensation.

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dc.contributor.authorJardin, Isaac
dc.contributor.authorLopez, Jose J
dc.contributor.authorDiez, Raquel
dc.contributor.authorSanchez-Collado, Jose
dc.contributor.authorCantonero, Carlos
dc.contributor.authorAlbarran, Letizia
dc.contributor.authorWoodard, Geoffrey E
dc.contributor.authorRedondo, Pedro C
dc.contributor.authorSalido, Gines M
dc.contributor.authorSmani, Tarik
dc.contributor.authorRosado, Juan A
dc.date.accessioned2023-01-25T09:48:00Z
dc.date.available2023-01-25T09:48:00Z
dc.date.issued2017-06-09
dc.description.abstractAccording to the International Association for the Study of Pain (IASP) pain is characterized as an "unpleasant sensory and emotional experience associated with actual or potential tissue damage". The TRP super-family, compressing up to 28 isoforms in mammals, mediates a myriad of physiological and pathophysiological processes, pain among them. TRP channel might be constituted by similar or different TRP subunits, which will result in the formation of homomeric or heteromeric channels with distinct properties and functions. In this review we will discuss about the function of TRPs in pain, focusing on TRP channles that participate in the transduction of noxious sensation, especially TRPV1 and TRPA1, their expression in nociceptors and their sensitivity to a large number of physical and chemical stimuli.
dc.description.versionSi
dc.identifier.citationJardín I, López JJ, Diez R, Sánchez-Collado J, Cantonero C, Albarrán L, et al. TRPs in Pain Sensation. Front Physiol. 2017 Jun 9;8:392.
dc.identifier.doi10.3389/fphys.2017.00392
dc.identifier.issn1664-042X
dc.identifier.pmcPMC5465271
dc.identifier.pmid28649203
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465271/pdf
dc.identifier.unpaywallURLhttps://www.frontiersin.org/articles/10.3389/fphys.2017.00392/pdf
dc.identifier.urihttp://hdl.handle.net/10668/11342
dc.journal.titleFrontiers in physiology
dc.journal.titleabbreviationFront Physiol
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.page.number10
dc.provenanceRealizada la curación de contenido 11/04/2025
dc.publisherFrontiers Research Foundation
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
dc.relation.publisherversionhttps://doi.org/10.3389/fphys.2017.00392
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTRPA1
dc.subjectTRPV1
dc.subjectTRPs
dc.subjectcalcium entry
dc.subjectnoxious sensation
dc.subject.decsVolición
dc.subject.decsAsociación
dc.subject.decsRevisión
dc.subject.decsTejidos
dc.subject.decsIsoformas de proteínas
dc.subject.decsNociceptores
dc.subject.decsSensación
dc.subject.meshNociceptors
dc.subject.meshSensation
dc.subject.meshPressure
dc.subject.meshMammals
dc.subject.meshAnimals
dc.titleTRPs in Pain Sensation.
dc.typeReview
dc.type.hasVersionVoR
dc.volume.number8
dspace.entity.typePublication

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