Publication: TRPs in Pain Sensation.
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Identifiers
Date
2017-06-09
Authors
Jardin, Isaac
Lopez, Jose J
Diez, Raquel
Sanchez-Collado, Jose
Cantonero, Carlos
Albarran, Letizia
Woodard, Geoffrey E
Redondo, Pedro C
Salido, Gines M
Smani, Tarik
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Research Foundation
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Abstract
According to the International Association for the Study of Pain (IASP) pain is characterized as an "unpleasant sensory and emotional experience associated with actual or potential tissue damage". The TRP super-family, compressing up to 28 isoforms in mammals, mediates a myriad of physiological and pathophysiological processes, pain among them. TRP channel might be constituted by similar or different TRP subunits, which will result in the formation of homomeric or heteromeric channels with distinct properties and functions. In this review we will discuss about the function of TRPs in pain, focusing on TRP channles that participate in the transduction of noxious sensation, especially TRPV1 and TRPA1, their expression in nociceptors and their sensitivity to a large number of physical and chemical stimuli.
Description
MeSH Terms
Nociceptors
Sensation
Pressure
Mammals
Animals
Sensation
Pressure
Mammals
Animals
DeCS Terms
Volición
Asociación
Revisión
Tejidos
Isoformas de proteínas
Nociceptores
Sensación
Asociación
Revisión
Tejidos
Isoformas de proteínas
Nociceptores
Sensación
CIE Terms
Keywords
TRPA1, TRPV1, TRPs, calcium entry, noxious sensation
Citation
Jardín I, López JJ, Diez R, Sánchez-Collado J, Cantonero C, Albarrán L, et al. TRPs in Pain Sensation. Front Physiol. 2017 Jun 9;8:392.