Publication:
A guiding torch at the poles: the multiple roles of spindle microtubule-organizing centers during cell division.

No Thumbnail Available

Date

2020-05-13

Authors

Rincón, Ana M
Monje-Casas, Fernando

Advisors

Journal Title

Journal ISSN

Volume Title

Publisher

Metrics
Google Scholar
Export

Research Projects

Organizational Units

Journal Issue

Abstract

The spindle constitutes the cellular machinery that enables the segregation of the chromosomes during eukaryotic cell division. The microtubules that form this fascinating and complex genome distribution system emanate from specialized structures located at both its poles and known as microtubule-organizing centers (MTOCs). Beyond their structural function, the spindle MTOCs play fundamental roles in cell cycle control, the activation and functionality of the mitotic checkpoints and during cellular aging. This review highlights the pivotal importance of spindle-associated MTOCs in multiple cellular processes and their central role as key regulatory hubs where diverse intracellular signals are integrated and coordinated to ensure the successful completion of cell division and the maintenance of the replicative lifespan.

Description

MeSH Terms

Animals
Cell Division
Cellular Senescence
Humans
Microtubule-Organizing Center
Signal Transduction
Spindle Apparatus

DeCS Terms

CIE Terms

Keywords

MTOC, aging, centrosome, meiosis, mitosis, spb

Citation