RT Journal Article
T1 A guiding torch at the poles: the multiple roles of spindle microtubule-organizing centers during cell division.
A1 Rincón, Ana M
A1 Monje-Casas, Fernando
K1 MTOC
K1 aging
K1 centrosome
K1 meiosis
K1 mitosis
K1 spb
AB The spindle constitutes the cellular machinery that enables the segregation of the chromosomes during eukaryotic cell division. The microtubules that form this fascinating and complex genome distribution system emanate from specialized structures located at both its poles and known as microtubule-organizing centers (MTOCs). Beyond their structural function, the spindle MTOCs play fundamental roles in cell cycle control, the activation and functionality of the mitotic checkpoints and during cellular aging. This review highlights the pivotal importance of spindle-associated MTOCs in multiple cellular processes and their central role as key regulatory hubs where diverse intracellular signals are integrated and coordinated to ensure the successful completion of cell division and the maintenance of the replicative lifespan.
YR 2020
FD 2020-05-13
LK http://hdl.handle.net/10668/15556
UL http://hdl.handle.net/10668/15556
LA en
DS RISalud
RD Apr 5, 2025