Publication:
Silk fibroin nanoparticles enhance quercetin immunomodulatory properties in DSS-induced mouse colitis.

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Date

2021-07-21

Authors

Diez-Echave, Patricia
Ruiz-Malagon, Antonio Jesus
Molina-Tijeras, Jose Alberto
Hidalgo-Garcia, Laura
Vezza, Teresa
Cenis-Cifuentes, Laura
Rodriguez-Sojo, María Jesus
Cenis, Jose Luis
Rodriguez-Cabezas, Maria Elena
Rodriguez-Nogales, Alba

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Elsevier BV
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Abstract

Inflammatory bowel disease (IBD) is a chronic and idiopathic inflammatory disorder affecting the gastrointestinal tract. The pharmacological treatments used currently for its treatment lack efficacy, so new therapeutic strategies should be developed. In this context, flavonoids loaded in biopolymeric nanoparticles can be considered as novel promising candidates. The aim of the present study was to evaluate the intestinal anti-inflammatory effects of quercetin when is administered loaded in silk fibroin nanoparticles (QSFN) in the dextran sulphate sodium experimental model of mouse colitis, which displays some similarities to human IBD. Previously characterized quercetin-loaded silk fibroin nanoparticles (QSFN). QSFN showed a reversible aggregation profile induced by the acidification of the solution but did not affect the loaded quercetin. Daily administration of QSFN significantly reduced disease activity index values compared to the control colitic group. This beneficial effect was not only corroborated by the histological examination of the colonic specimens but also the improvement of the colonic expression of the different proinflammatory cytokines (Tnf-α, Il-1β, Il-6, Mcp-1, Icam-1, Nlrp3 and iNOS). Therefore, these data suggest that QSFN could be a promising alternative to current treatments as a drug delivery system for IBD treatment.

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MeSH Terms

Animals
Colitis
Colon
Cytokines
Dextran Sulfate
Disease Models, Animal
Fibroins
Mice
Mice, Inbred C57BL
Nanoparticles
Quercetin

DeCS Terms

Animales
Citocinas
Colitis
Colon
Fibroínas
Modelos animales de enfermedad
Nanopartículas
Quercetina
Ratones
Ratones endogámicos C57BL
Sulfato de Dextran

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Keywords

Anti-inflammatory, Drug loading, Inflammatory bowel disease, Quercetin, Silk fibroin nanoparticles

Citation

Diez-Echave P, Ruiz-Malagón AJ, Molina-Tijeras JA, Hidalgo-García L, Vezza T, Cenis-Cifuentes L, et al. Silk fibroin nanoparticles enhance quercetin immunomodulatory properties in DSS-induced mouse colitis. Int J Pharm. 2021 Sep 5;606:120935.