RT Journal Article
T1 Silk fibroin nanoparticles enhance quercetin immunomodulatory properties in DSS-induced mouse colitis.
A1 Diez-Echave, Patricia
A1 Ruiz-Malagon, Antonio Jesus
A1 Molina-Tijeras, Jose Alberto
A1 Hidalgo-Garcia, Laura
A1 Vezza, Teresa
A1 Cenis-Cifuentes, Laura
A1 Rodriguez-Sojo, María Jesus
A1 Cenis, Jose Luis
A1 Rodriguez-Cabezas, Maria Elena
A1 Rodriguez-Nogales, Alba
A1 Galvez, Julio
A1 Lozano-Perez, Antonio Abel
K1 Anti-inflammatory
K1 Drug loading
K1 Inflammatory bowel disease
K1 Quercetin
K1 Silk fibroin nanoparticles
AB Inflammatory bowel disease (IBD) is a chronic and idiopathic inflammatory disorder affecting the gastrointestinal tract. The pharmacological treatments used currently for its treatment lack efficacy, so new therapeutic strategies should be developed. In this context, flavonoids loaded in biopolymeric nanoparticles can be considered as novel promising candidates. The aim of the present study was to evaluate the intestinal anti-inflammatory effects of quercetin when is administered loaded in silk fibroin nanoparticles (QSFN) in the dextran sulphate sodium experimental model of mouse colitis, which displays some similarities to human IBD. Previously characterized quercetin-loaded silk fibroin nanoparticles (QSFN). QSFN showed a reversible aggregation profile induced by the acidification of the solution but did not affect the loaded quercetin. Daily administration of QSFN significantly reduced disease activity index values compared to the control colitic group. This beneficial effect was not only corroborated by the histological examination of the colonic specimens but also the improvement of the colonic expression of the different proinflammatory cytokines (Tnf-α, Il-1β, Il-6, Mcp-1, Icam-1, Nlrp3 and iNOS). Therefore, these data suggest that QSFN could be a promising alternative to current treatments as a drug delivery system for IBD treatment.
PB Elsevier BV
YR 2021
FD 2021-07-21
LK http://hdl.handle.net/10668/18262
UL http://hdl.handle.net/10668/18262
LA en
NO Diez-Echave P, Ruiz-Malagón AJ, Molina-Tijeras JA, Hidalgo-García L, Vezza T, Cenis-Cifuentes L, et al. Silk fibroin nanoparticles enhance quercetin immunomodulatory properties in DSS-induced mouse colitis. Int J Pharm. 2021 Sep 5;606:120935.
DS RISalud
RD Apr 19, 2025