Publication: Visual memory dysfunction as a neurocognitive endophenotype in bipolar disorder patients and their unaffected relatives. Evidence from a 5-year follow-up Valencia study.
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Date
2019-07-02
Authors
Correa-Ghisays, Patricia
Sánchez-Ortí, Joan Vicent
Ayesa-Arriola, Rosa
Setién-Suero, Esther
Balanzá-Martínez, Vicent
Selva-Vera, Gabriel
Ruiz-Ruiz, Juan Carlos
Vila-Francés, Joan
Martinez-Aran, Anabel
Vivas-Lalinde, Juliana
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Abstract
Scarce research has focused on Visual Memory (VM) deficits as a possible neurocognitive endophenotype of bipolar disorder (BD). The main aim of this longitudinal, family study with healthy controls was to explore whether VM dysfunction represents a neurocognitive endophenotype of BD. Assessment of VM by Rey-Osterrieth Complex Figure Test (ROCF) was carried out on a sample of 317 subjects, including 140 patients with BD, 60 unaffected first-degree relatives (BD-Rel), and 117 genetically-unrelated healthy controls (HC), on three occasions over a 5-year period (T1, T2, and T3). BD-Rel group scores were analyzed only at T1 and T2. Performance of BD patients was significantly worse than the HC group (p Important attrition in BD-Rel group over time was detected, which precluded analysis at T3. BD patients show significant deficits in VM that remain stable over time, even after controlling sociodemographic and clinical variables. Unaffected relatives also show stable deficits in VM. Accordingly, the deficit in VM could be considered a potential endophenotype of BD, which in turn may be useful as a predictor of the evolution of the disease. Further studies are needed to confirm these findings.
Description
MeSH Terms
Adolescent
Adult
Aged
Bipolar Disorder
Cognition
Endophenotypes
Female
Follow-Up Studies
Health Status
Humans
Longitudinal Studies
Male
Memory Disorders
Middle Aged
Neuropsychological Tests
Young Adult
Adult
Aged
Bipolar Disorder
Cognition
Endophenotypes
Female
Follow-Up Studies
Health Status
Humans
Longitudinal Studies
Male
Memory Disorders
Middle Aged
Neuropsychological Tests
Young Adult
DeCS Terms
CIE Terms
Keywords
Bipolar disorder, Endophenotype, Family study, Longitudinal study, Neurocognition, Visual memory