RT Journal Article
T1 Visual memory dysfunction as a neurocognitive endophenotype in bipolar disorder patients and their unaffected relatives. Evidence from a 5-year follow-up Valencia study.
A1 Correa-Ghisays, Patricia
A1 Sánchez-Ortí, Joan Vicent
A1 Ayesa-Arriola, Rosa
A1 Setién-Suero, Esther
A1 Balanzá-Martínez, Vicent
A1 Selva-Vera, Gabriel
A1 Ruiz-Ruiz, Juan Carlos
A1 Vila-Francés, Joan
A1 Martinez-Aran, Anabel
A1 Vivas-Lalinde, Juliana
A1 Conforte-Molina, Candela
A1 San-Martín, Constanza
A1 Martínez-Pérez, Carlos
A1 Fuentes-Durá, Inmaculada
A1 Crespo-Facorro, Benedicto
A1 Tabarés-Seisdedos, Rafael
K1 Bipolar disorder
K1 Endophenotype
K1 Family study
K1 Longitudinal study
K1 Neurocognition
K1 Visual memory
AB Scarce research has focused on Visual Memory (VM) deficits as a possible neurocognitive endophenotype of bipolar disorder (BD). The main aim of this longitudinal, family study with healthy controls was to explore whether VM dysfunction represents a neurocognitive endophenotype of BD. Assessment of VM by Rey-Osterrieth Complex Figure Test (ROCF) was carried out on a sample of 317 subjects, including 140 patients with BD, 60 unaffected first-degree relatives (BD-Rel), and 117 genetically-unrelated healthy controls (HC), on three occasions over a 5-year period (T1, T2, and T3). BD-Rel group scores were analyzed only at T1 and T2. Performance of BD patients was significantly worse than the HC group (p  Important attrition in BD-Rel group over time was detected, which precluded analysis at T3. BD patients show significant deficits in VM that remain stable over time, even after controlling sociodemographic and clinical variables. Unaffected relatives also show stable deficits in VM. Accordingly, the deficit in VM could be considered a potential endophenotype of BD, which in turn may be useful as a predictor of the evolution of the disease. Further studies are needed to confirm these findings.
YR 2019
FD 2019-07-02
LK http://hdl.handle.net/10668/14238
UL http://hdl.handle.net/10668/14238
LA en
DS RISalud
RD Apr 9, 2025