Publication:
Relationship of Zonulin with Serum PCSK9 Levels after a High Fat Load in a Population of Obese Subjects.

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Date

2020-05-11

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Molina-Vega, María
Castellano-Castillo, Daniel
Sánchez-Alcoholado, Lidia
Plaza-Andrade, Isaac
Perera-Martin, Gabriel
Cabrera-Mulero, Amanda
Fernández-García, Jose Carlos
Ramos-Molina, Bruno
Cardona, Fernando
Tinahones, Francisco J

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Despite the fact that circulating levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) remain unchanged after fat load in healthy lean individuals, PCSK9 has been suggested to have a role in postprandial lipemia regulation in obese individuals. On the other hand, intestinal permeability and endotoxemia have been observed to increase more in obese individuals than in non-obese individuals after a lipid load. This study aimed to analyze the relationship between PCSK9, intestinal permeability, and endotoxemia after a high fat load in obese individuals. We included 39 individuals with morbid obesity. Serum PCSK9 levels, intestinal permeability marker (zonulin), endotoxemia markers (LPS and LBP), and lipid parameters were measured before and after 3 h of fat load. A significant rise in triglycerides, apolipoprotein A1, zonulin, LPS, and LBP, and a significant decline in PCSK9, were observed after a lipid load. Linear regression analysis showed that low-density lipoprotein cholesterol (LDL-C) was independently related to PCSK9 at baseline, whereas both zonulin and LDL-C were independently related to PCSK9 levels after fat load. A relationship between zonulin and PCSK9 levels after fat load in individuals with morbid obesity may exist.

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Adult
Diet, High-Fat
Female
Haptoglobins
Humans
Linear Models
Male
Obesity
Proprotein Convertase 9
Protein Precursors

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PCSK9, apolipoproteins, high fat load, intestinal permeability, zonulin

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