RT Journal Article
T1 Relationship of Zonulin with Serum PCSK9 Levels after a High Fat Load in a Population of Obese Subjects.
A1 Molina-Vega, María
A1 Castellano-Castillo, Daniel
A1 Sánchez-Alcoholado, Lidia
A1 Plaza-Andrade, Isaac
A1 Perera-Martin, Gabriel
A1 Cabrera-Mulero, Amanda
A1 Fernández-García, Jose Carlos
A1 Ramos-Molina, Bruno
A1 Cardona, Fernando
A1 Tinahones, Francisco J
K1 PCSK9
K1 apolipoproteins
K1 high fat load
K1 intestinal permeability
K1 zonulin
AB Despite the fact that circulating levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) remain unchanged after fat load in healthy lean individuals, PCSK9 has been suggested to have a role in postprandial lipemia regulation in obese individuals. On the other hand, intestinal permeability and endotoxemia have been observed to increase more in obese individuals than in non-obese individuals after a lipid load. This study aimed to analyze the relationship between PCSK9, intestinal permeability, and endotoxemia after a high fat load in obese individuals. We included 39 individuals with morbid obesity. Serum PCSK9 levels, intestinal permeability marker (zonulin), endotoxemia markers (LPS and LBP), and lipid parameters were measured before and after 3 h of fat load. A significant rise in triglycerides, apolipoprotein A1, zonulin, LPS, and LBP, and a significant decline in PCSK9, were observed after a lipid load. Linear regression analysis showed that low-density lipoprotein cholesterol (LDL-C) was independently related to PCSK9 at baseline, whereas both zonulin and LDL-C were independently related to PCSK9 levels after fat load. A relationship between zonulin and PCSK9 levels after fat load in individuals with morbid obesity may exist.
YR 2020
FD 2020-05-11
LK http://hdl.handle.net/10668/15562
UL http://hdl.handle.net/10668/15562
LA en
DS RISalud
RD Apr 6, 2025