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The Analysis of Platelet-Derived circRNA Repertoire as Potential Diagnostic Biomarker for Non-Small Cell Lung Cancer.

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dc.contributor.authorD'Ambrosi, Silvia
dc.contributor.authorVisser, Allerdien
dc.contributor.authorAntunes-Ferreira, Mafalda
dc.contributor.authorPoutsma, Ankie
dc.contributor.authorGiannoukakos, Stavros
dc.contributor.authorSol, Nik
dc.contributor.authorSabrkhany, Siamack
dc.contributor.authorBahce, Idris
dc.contributor.authorKuijpers, Marijke J E
dc.contributor.authorOude Egbrink, Mirjam G A
dc.contributor.authorGriffioen, Arjan W
dc.contributor.authorBest, Myron G
dc.contributor.authorKoppers-Lalic, Danijela
dc.contributor.authorOudejans, Cees
dc.contributor.authorWürdinger, Thomas
dc.contributor.funderEuropean Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie
dc.contributor.funderCancer Center Amsterdam (CCA) Foundation
dc.date.accessioned2023-02-09T11:51:43Z
dc.date.available2023-02-09T11:51:43Z
dc.date.issued2021-09-13
dc.description.abstractTumor-educated Platelets (TEPs) have emerged as rich biosources of cancer-related RNA profiles in liquid biopsies applicable for cancer detection. Although human blood platelets have been found to be enriched in circular RNA (circRNA), no studies have investigated the potential of circRNA as platelet-derived biomarkers for cancer. In this proof-of-concept study, we examine whether the circRNA signature of blood platelets can be used as a liquid biopsy biomarker for the detection of non-small cell lung cancer (NSCLC). We analyzed the total RNA, extracted from the platelet samples collected from NSCLC patients and asymptomatic individuals, using RNA sequencing (RNA-Seq). Identification and quantification of known and novel circRNAs were performed using the accurate CircRNA finder suite (ACFS), followed by the differential transcript expression analysis using a modified version of our thromboSeq software. Out of 4732 detected circRNAs, we identified 411 circRNAs that are significantly (p-value
dc.description.versionSi
dc.identifier.citationD'Ambrosi S, Visser A, Antunes-Ferreira M, Poutsma A, Giannoukakos S, Sol N, et al. The Analysis of Platelet-Derived circRNA Repertoire as Potential Diagnostic Biomarker for Non-Small Cell Lung Cancer. Cancers (Basel). 2021 Sep 16;13(18):4644.
dc.identifier.doi10.3390/cancers13184644
dc.identifier.issn2072-6694
dc.identifier.pmcPMC8468408
dc.identifier.pmid34572871
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468408/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2072-6694/13/18/4644/pdf?version=1631790779
dc.identifier.urihttp://hdl.handle.net/10668/18559
dc.issue.number18
dc.journal.titleCancers
dc.journal.titleabbreviationCancers (Basel)
dc.language.isoen
dc.organizationInstituto de Investigación Biosanitaria ibs. GRANADA
dc.page.number13
dc.provenanceRealizada la curación de contenido 30/08/2024
dc.publisherMDPI AG
dc.pubmedtypeJournal Article
dc.relation.projectID765492
dc.relation.projectIDCCA2017-2-16
dc.relation.publisherversionhttps://www.mdpi.com/resolver?pii=cancers13184644
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectbiomarkers
dc.subjectcircular RNA
dc.subjectliquid biopsy
dc.subjectnon-small cell lung cancer
dc.subjectplatelets
dc.subject.decsARN
dc.subject.decsARN Circular
dc.subject.decsAnálisis de secuencia de ARN
dc.subject.decsCarcinoma de pulmón decélulas no pequeñas
dc.subject.decsHumanos
dc.subject.decsNeoplasias pulmonares
dc.subject.decsPerfilación de la expresión génica plaquetas
dc.subject.decsProgramas informáticos
dc.subject.decsProteína de interacción con receptores nucleares 1
dc.subject.decsRNA-Seq
dc.subject.decsReacción en cadena de la polimerasa
dc.subject.meshHumans
dc.subject.meshRNA
dc.subject.meshRNA, Circular
dc.subject.meshCarcinoma, Non-Small-Cell Lung
dc.subject.meshRNA-Seq
dc.subject.meshReverse Transcription
dc.subject.meshDown-Regulation
dc.subject.meshNuclear Receptor Interacting Protein 1
dc.subject.meshBlood Platelets
dc.subject.meshLung Neoplasms
dc.subject.meshGene Expression Profiling
dc.subject.meshSequence Analysis, RNA
dc.subject.meshSoftware
dc.subject.meshPolymerase Chain Reaction
dc.titleThe Analysis of Platelet-Derived circRNA Repertoire as Potential Diagnostic Biomarker for Non-Small Cell Lung Cancer.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number13
dspace.entity.typePublication

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