Publication:
Night Shift Work, Chronotype, Sleep Duration, and Prostate Cancer Risk: CAPLIFE Study.

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Date

2020-08-26

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Lozano-Lorca, Macarena
Olmedo-Requena, Rocio
Vega-Galindo, Maria-Victoria
Vazquez-Alonso, Fernando
Jimenez-Pacheco, Antonio
Salcedo-Bellido, Inmaculada
Sanchez-Perez, Maria-Jose
Jimenez-Moleon, Jose-Juan

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MDPI AG
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Abstract

To analyze the association between prostate cancer (PCa) risk and night shift work, chronotype, and sleep duration in the context of a population-based case-control study of incident prostate cancer in Spain, a total of 465 PCa cases and 410 controls were analyzed. Selection criteria were: (i) age 40-80 years, and (ii) residence in the coverage area of the reference hospitals for ≥6 months before recruitment. Exposure variables were: (i) night shift work (permanent or rotating); (ii) chronotype: morning, neither, or evening (Munich ChronoType Questionnaire) and (iii) sleep duration according to the recommendations of the American National Sleep Foundation. PCa aggressiveness was determined according to the International Society of Urology Pathology classification. Adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) were estimated using logistic regression models. Night shift work was associated with PCa, aOR = 1.47 (95% CI 1.02-2.11), especially for rotating night shifts, aOR = 1.73 (95% CI 1.09-2.75). The magnitude of the association between ever night work and PCa was higher in evening subjects with aOR = 3.14 (95% CI 0.91-10.76) than in morning chronotypes with an aOR = 1.25 (95% CI 0.78-2.00). Working night shifts, especially rotating night shifts, could increase PCa risk. This risk may be higher in people with an evening chronotype.

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MeSH Terms

Aged
Case-Control Studies
Circadian Rhythm
Humans
Male
Middle Aged
Prostatic Neoplasms
Shift Work Schedule
Sleep
Spain
Surveys and Questionnaires
Work Schedule Tolerance

DeCS Terms

Anciano
Encuestas y cuestionarios
España
Estudios de casos y controles
Horario de trabajo por turnos
Neoplasias de la próstata
Persona de mediana edad
Ritmo circadiano
Sueño
Tolerancia al trabajo programado

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Keywords

CAPLIFE study, case-control studies, circadian rhythm, prostatic neoplasms, shift work schedule, sleep

Citation

Lozano-Lorca M, Olmedo-Requena R, Vega-Galindo MV, Vázquez-Alonso F, Jiménez-Pacheco A, Salcedo-Bellido I, et al. Night Shift Work, Chronotype, Sleep Duration, and Prostate Cancer Risk: CAPLIFE Study. Int J Environ Res Public Health. 2020 Aug 29;17(17):6300.