The Epigenetics of Glioma Stem Cells: A Brief Overview

Valor, Luis M.; Hervás-Corpión, Irati

Publication:
The Epigenetics of Glioma Stem Cells: A Brief Overview

dc.contributor.author	Valor, Luis M.
dc.contributor.author	Hervás-Corpión, Irati
dc.contributor.authoraffiliation	[Valor,LM; Hervás-Corpión,I] Unidad de Investigación, Hospital Universitario Puerta del Mar, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, Spain.
dc.contributor.funder	LV is supported by the Plan Propio INiBICA (Grant L19-07IN-CO07) and by the Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+i, financed by the Instituto de Salud Carlos III and Fondo Europeo de Desarrollo Regional 2014-2020 (Grants CP15/00180 and PI16/00722). LV is the recipient of a Miguel Servet I contract (CP15/00180) financed by the Instituto de Salud Carlos III and Fondo Social Europeo 2014-2020, Programa Estatal de Promoción del Talento y su empleabilidad en I+D+i.
dc.date.accessioned	2022-04-20T09:44:27Z
dc.date.available	2022-04-20T09:44:27Z
dc.date.issued	2020-12-02
dc.description.abstract	Glioma stem cells (GSCs) are crucial in the formation, perpetuation and recurrence of glioblastomas (GBs) due to their self-renewal and proliferation properties. Although GSCs share cellular and molecular characteristics with neural stem cells (NSCs), GSCs show unique transcriptional and epigenetic features that may explain their relevant role in GB and may constitute druggable targets for novel therapeutic approaches. In this review, we will summarize the most important findings in GSCs concerning epigenetic-dependent mechanisms.	es_ES
dc.description.version	Yes	es_ES
dc.identifier.citation	Valor LM, Hervás-Corpión I. The Epigenetics of Glioma Stem Cells: A Brief Overview. Front Oncol. 2020 Dec 2;10:602378	es_ES
dc.identifier.doi	10.3389/fonc.2020.602378	es_ES
dc.identifier.essn	2234-943X
dc.identifier.pmc	PMC7738619
dc.identifier.pmid	33344253	es_ES
dc.identifier.uri	http://hdl.handle.net/10668/3546
dc.journal.title	Frontiers in Oncology
dc.language.iso	en
dc.page.number	8 p.
dc.publisher	Frontiers	es_ES
dc.relation.publisherversion	https://www.frontiersin.org/articles/10.3389/fonc.2020.602378/full	es_ES
dc.rights	Atribución 4.0 Internacional	*
dc.rights.accessRights	open access
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Glioblastoma	es_ES
dc.subject	Histone	es_ES
dc.subject	DNA	es_ES
dc.subject	Methylation	es_ES
dc.subject	Acetylation	es_ES
dc.subject	Polycomb	es_ES
dc.subject	H3.3	es_ES
dc.subject	HDACi	es_ES
dc.subject	Histonas	es_ES
dc.subject	ADN	es_ES
dc.subject	Metilación	es_ES
dc.subject	Acetilación	es_ES
dc.subject.mesh	Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Nerve Tissue::Neuroectodermal Tumors::Neoplasms, Neuroepithelial::Glioma::Astrocytoma::Glioblastoma	es_ES
dc.subject.mesh	Medical Subject Headings::Anatomy::Cells::Stem Cells::Neoplastic Stem Cells	es_ES
dc.subject.mesh	Medical Subject Headings::Anatomy::Cells::Stem Cells::Neural Stem Cells	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic	es_ES
dc.subject.mesh	Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Methylation	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Acylation::Acetylation	es_ES
dc.title	The Epigenetics of Glioma Stem Cells: A Brief Overview	es_ES
dc.type	review article
dc.type.hasVersion	VoR
dspace.entity.type	Publication