Publication: Intergenerational transmission of the positive effects of physical exercise on brain and cognition.
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Date
2019-04-22
Authors
McGreevy, Kerry R
Tezanos, Patricia
Ferreiro-Villar, Iria
Pallé, Anna
Moreno-Serrano, Marta
Esteve-Codina, Anna
Lamas-Toranzo, Ismael
Bermejo-Álvarez, Pablo
Fernández-Punzano, Julia
Martín-Montalvo, Alejandro
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Abstract
Physical exercise has positive effects on cognition, but very little is known about the inheritance of these effects to sedentary offspring and the mechanisms involved. Here, we use a patrilineal design in mice to test the transmission of effects from the same father (before or after training) and from different fathers to compare sedentary- and runner-father progenies. Behavioral, stereological, and whole-genome sequence analyses reveal that paternal cognition improvement is inherited by the offspring, along with increased adult neurogenesis, greater mitochondrial citrate synthase activity, and modulation of the adult hippocampal gene expression profile. These results demonstrate the inheritance of exercise-induced cognition enhancement through the germline, pointing to paternal physical activity as a direct factor driving offspring's brain physiology and cognitive behavior.
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MeSH Terms
Animals
Brain
Cognition
Fathers
Female
Gene Expression
Male
Mice
Paternal Inheritance
Pregnancy
Running
Brain
Cognition
Fathers
Female
Gene Expression
Male
Mice
Paternal Inheritance
Pregnancy
Running
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Keywords
adult hippocampal neurogenesis, cognition traits, intergenerational inheritance, mitochondria, moderate physical exercise