RT Journal Article
T1 Intergenerational transmission of the positive effects of physical exercise on brain and cognition.
A1 McGreevy, Kerry R
A1 Tezanos, Patricia
A1 Ferreiro-Villar, Iria
A1 Pallé, Anna
A1 Moreno-Serrano, Marta
A1 Esteve-Codina, Anna
A1 Lamas-Toranzo, Ismael
A1 Bermejo-Álvarez, Pablo
A1 Fernández-Punzano, Julia
A1 Martín-Montalvo, Alejandro
A1 Montalbán, Raquel
A1 Ferrón, Sacri R
A1 Radford, Elizabeth J
A1 Fontán-Lozano, Ángela
A1 Trejo, José Luis
K1 adult hippocampal neurogenesis
K1 cognition traits
K1 intergenerational inheritance
K1 mitochondria
K1 moderate physical exercise
AB Physical exercise has positive effects on cognition, but very little is known about the inheritance of these effects to sedentary offspring and the mechanisms involved. Here, we use a patrilineal design in mice to test the transmission of effects from the same father (before or after training) and from different fathers to compare sedentary- and runner-father progenies. Behavioral, stereological, and whole-genome sequence analyses reveal that paternal cognition improvement is inherited by the offspring, along with increased adult neurogenesis, greater mitochondrial citrate synthase activity, and modulation of the adult hippocampal gene expression profile. These results demonstrate the inheritance of exercise-induced cognition enhancement through the germline, pointing to paternal physical activity as a direct factor driving offspring's brain physiology and cognitive behavior.
YR 2019
FD 2019-04-22
LK http://hdl.handle.net/10668/13864
UL http://hdl.handle.net/10668/13864
LA en
DS RISalud
RD Apr 17, 2025