Publication:
Nanomedicine to Overcome Multidrug Resistance Mechanisms in Colon and Pancreatic Cancer: Recent Progress

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Date

2021-04-24

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Ortíz, Raúl
Quiñonero, Francisco
García-Pinel, Beatriz
Fuel, Marco
Mesas, Cristina
Cabeza, Laura
Melguizo, Consolación
Prados, Jose

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MDPI
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Abstract

The development of drug resistance is one of the main causes of cancer treatment failure. This phenomenon occurs very frequently in different types of cancer, including colon and pancreatic cancers. However, the underlying molecular mechanisms are not fully understood. In recent years, nanomedicine has improved the delivery and efficacy of drugs, and has decreased their side effects. In addition, it has allowed to design drugs capable of avoiding certain resistance mechanisms of tumors. In this article, we review the main resistance mechanisms in colon and pancreatic cancers, along with the most relevant strategies offered by nanodrugs to overcome this obstacle. These strategies include the inhibition of efflux pumps, the use of specific targets, the development of nanomedicines affecting the environment of cancer-specific tissues, the modulation of DNA repair mechanisms or RNA (miRNA), and specific approaches to damage cancer stem cells, among others. This review aims to illustrate how advanced nanoformulations, including polymeric conjugates, micelles, dendrimers, liposomes, metallic and carbon-based nanoparticles, are allowing to overcome one of the main limitations in the treatment of colon and pancreatic cancers. The future development of nanomedicine opens new horizons for cancer treatment.

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Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Nanotechnology::Nanomedicine
Medical Subject Headings::Chemicals and Drugs::Biomedical and Dental Materials::Membranes, Artificial::Liposomes
Medical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Micelles
Medical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Dendrimers
Medical Subject Headings::Technology and Food and Beverages::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles
Medical Subject Headings::Anatomy::Cells::Stem Cells::Neoplastic Stem Cells
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Pancreatic Neoplasms
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome::Treatment Failure
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Drug Resistance
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Repair
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs
Medical Subject Headings::Anatomy::Digestive System::Gastrointestinal Tract::Intestines::Intestine, Large::Colon

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Drug resistance, Colon cancer, Pancreatic cancer, Nanomedicine, PARP, miRNA, Tumor microenvironment, Resistencia a medicamentos, Neoplasias del colon, Neoplasias pancreáticas, Nanomedicina, Poli(ADP-Ribosa) polimerasas, MicroARNs, Microambiente tumoral

Citation

Ortíz R, Quiñonero F, García-Pinel B, Fuel M, Mesas C, Cabeza L, et al. Nanomedicine to Overcome Multidrug Resistance Mechanisms in Colon and Pancreatic Cancer: Recent Progress. Cancers. 2021 Apr 24;13(9):2058