RT Journal Article
T1 Nanomedicine to Overcome Multidrug Resistance Mechanisms in Colon and Pancreatic Cancer: Recent Progress
A1 Ortíz, Raúl
A1 Quiñonero, Francisco
A1 García-Pinel, Beatriz
A1 Fuel, Marco
A1 Mesas, Cristina
A1 Cabeza, Laura
A1 Melguizo, Consolación
A1 Prados, Jose
K1 Drug resistance
K1 Colon cancer
K1 Pancreatic cancer
K1 Nanomedicine
K1 PARP
K1 miRNA
K1 Tumor microenvironment
K1 Resistencia a medicamentos
K1 Neoplasias del colon
K1 Neoplasias pancreáticas
K1 Nanomedicina
K1 Poli(ADP-Ribosa) polimerasas
K1 MicroARNs
K1 Microambiente tumoral
AB The development of drug resistance is one of the main causes of cancer treatment failure. This phenomenon occurs very frequently in different types of cancer, including colon and pancreatic cancers. However, the underlying molecular mechanisms are not fully understood. In recent years, nanomedicine has improved the delivery and efficacy of drugs, and has decreased their side effects. In addition, it has allowed to design drugs capable of avoiding certain resistance mechanisms of tumors. In this article, we review the main resistance mechanisms in colon and pancreatic cancers, along with the most relevant strategies offered by nanodrugs to overcome this obstacle. These strategies include the inhibition of efflux pumps, the use of specific targets, the development of nanomedicines affecting the environment of cancer-specific tissues, the modulation of DNA repair mechanisms or RNA (miRNA), and specific approaches to damage cancer stem cells, among others. This review aims to illustrate how advanced nanoformulations, including polymeric conjugates, micelles, dendrimers, liposomes, metallic and carbon-based nanoparticles, are allowing to overcome one of the main limitations in the treatment of colon and pancreatic cancers. The future development of nanomedicine opens new horizons for cancer treatment.
PB MDPI
YR 2021
FD 2021-04-24
LK http://hdl.handle.net/10668/4177
UL http://hdl.handle.net/10668/4177
LA en
NO Ortíz R, Quiñonero F, García-Pinel B, Fuel M, Mesas C, Cabeza L, et al. Nanomedicine to Overcome Multidrug Resistance Mechanisms in Colon and Pancreatic Cancer: Recent Progress. Cancers. 2021 Apr 24;13(9):2058
DS RISalud
RD Apr 4, 2025