Publication:
A specific protein-enriched enteral formula decreases cortisolemia and improves plasma albumin and amino acid concentrations in elderly patients

Loading...
Thumbnail Image

Date

2010-07-13

Authors

Olza, Josune
Mesa, María D
Poyatos, Rafael M
Aguilera, Concepción M
Moreno-Torres, Rosario
Pérez, Milagros
Pérez de la Cruz, Antonio
Gil, Angel

Advisors

Journal Title

Journal ISSN

Volume Title

Publisher

BioMed Central
Metrics
Google Scholar
Export

Research Projects

Organizational Units

Journal Issue

Abstract

Background: Old age is associated with an involuntary and progressive but physiological loss of muscle mass. The aim of this study was to evaluate the effects of exclusive consumption for 6 months of a protein-enriched enteral diet with a relatively high content of branched-chain amino acids on albuminemia, cortisolemia, plasma aminoacids, insulin resistance, and inflammation biomarkers in elderly patients. Methods: Thirty-two patients from the Clinical Nutrition Outpatient Unit at our hospital exclusively consumed a protein-enriched enteral diet for 6 months. Data were collected at baseline and at 3 and 6 months on anthropometric and biochemical parameters and on plasma concentrations of amino acids, cortisol,adrenocorticotropic hormone, urea, creatinine, insulin resistance, and inflammation biomarkers. Results: The percentage of patients with albumin concentration below normal cut-off values decreased from 18% to 0% by the end of the study. At 6 months, concentrations of total plasma (p = 0.008) and essential amino acids(p = 0.011), especially branched-chain amino acids (p = 0.031), were higher versus baseline values, whereas 3-methylhistidine (p = 0.001), cortisol (p = 0.001) and adrenocorticotropic hormone (p = 0.004) levels were lower. Conclusions: Regular intake of specific protein-enriched enteral formula increases plasma essential amino acids, especially branched-chain amino acids, and decreases cortisol and 3-methylhistidine, while plasma urea and creatinine remain unchanged.

Description

MeSH Terms

Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Nutrition Therapy::Nutritional Support::Enteral Nutrition
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Neuromuscular Manifestations::Muscular Atrophy::Sarcopenia
Medical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Foods, Specialized::Food, Fortified

DeCS Terms

CIE Terms

Keywords

Anciano, Nutrición Enteral, Aminoácidos, Péptidos y Proteínas, Sarcopenia, Alimentos Fortificados

Citation