Publication: A specific protein-enriched enteral formula decreases cortisolemia and improves plasma albumin and amino acid concentrations in elderly patients
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Identifiers
Date
2010-07-13
Authors
Olza, Josune
Mesa, María D
Poyatos, Rafael M
Aguilera, Concepción M
Moreno-Torres, Rosario
Pérez, Milagros
Pérez de la Cruz, Antonio
Gil, Angel
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central
Abstract
Background: Old age is associated with an involuntary and progressive but physiological loss of muscle mass. The aim of this study was to evaluate the effects of exclusive consumption for 6 months of a protein-enriched enteral diet with a relatively high content of branched-chain amino acids on albuminemia, cortisolemia, plasma aminoacids, insulin resistance, and inflammation biomarkers in elderly patients.
Methods: Thirty-two patients from the Clinical Nutrition Outpatient Unit at our hospital exclusively consumed a protein-enriched enteral diet for 6 months. Data were collected at baseline and at 3 and 6 months on anthropometric and biochemical parameters and on plasma concentrations of amino acids, cortisol,adrenocorticotropic hormone, urea, creatinine, insulin resistance, and inflammation biomarkers.
Results: The percentage of patients with albumin concentration below normal cut-off values decreased from 18% to 0% by the end of the study. At 6 months, concentrations of total plasma (p = 0.008) and essential amino acids(p = 0.011), especially branched-chain amino acids (p = 0.031), were higher versus baseline values, whereas 3-methylhistidine (p = 0.001), cortisol (p = 0.001) and adrenocorticotropic hormone (p = 0.004) levels were lower.
Conclusions: Regular intake of specific protein-enriched enteral formula increases plasma essential amino acids, especially branched-chain amino acids, and decreases cortisol and 3-methylhistidine, while plasma urea and creatinine remain unchanged.
Description
MeSH Terms
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Nutrition Therapy::Nutritional Support::Enteral Nutrition
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Neuromuscular Manifestations::Muscular Atrophy::Sarcopenia
Medical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Foods, Specialized::Food, Fortified
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Nutrition Therapy::Nutritional Support::Enteral Nutrition
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Neuromuscular Manifestations::Muscular Atrophy::Sarcopenia
Medical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Foods, Specialized::Food, Fortified
DeCS Terms
CIE Terms
Keywords
Anciano, Nutrición Enteral, Aminoácidos, Péptidos y Proteínas, Sarcopenia, Alimentos Fortificados