RT Journal Article
T1 A specific protein-enriched enteral formula decreases cortisolemia and improves plasma albumin and amino acid concentrations in elderly patients
A1 Olza, Josune
A1 Mesa, María D
A1 Poyatos, Rafael M
A1 Aguilera, Concepción M
A1 Moreno-Torres, Rosario
A1 Pérez, Milagros
A1 Pérez de la Cruz, Antonio
A1 Gil, Angel
K1 Anciano
K1 Nutrición Enteral
K1 Aminoácidos, Péptidos y Proteínas
K1 Sarcopenia
K1 Alimentos Fortificados
AB Background: Old age is associated with an involuntary and progressive but physiological loss of muscle mass. The aim of this study was to evaluate the effects of exclusive consumption for 6 months of a protein-enriched enteral diet with a relatively high content of branched-chain amino acids on albuminemia, cortisolemia, plasma aminoacids, insulin resistance, and inflammation biomarkers in elderly patients.Methods: Thirty-two patients from the Clinical Nutrition Outpatient Unit at our hospital exclusively consumed a protein-enriched enteral diet for 6 months. Data were collected at baseline and at 3 and 6 months on anthropometric and biochemical parameters and on plasma concentrations of amino acids, cortisol,adrenocorticotropic hormone, urea, creatinine, insulin resistance, and inflammation biomarkers.Results: The percentage of patients with albumin concentration below normal cut-off values decreased from 18% to 0% by the end of the study. At 6 months, concentrations of total plasma (p = 0.008) and essential amino acids(p = 0.011), especially branched-chain amino acids (p = 0.031), were higher versus baseline values, whereas 3-methylhistidine (p = 0.001), cortisol (p = 0.001) and adrenocorticotropic hormone (p = 0.004) levels were lower.Conclusions: Regular intake of specific protein-enriched enteral formula increases plasma essential amino acids, especially branched-chain amino acids, and decreases cortisol and 3-methylhistidine, while plasma urea and creatinine remain unchanged.
PB BioMed Central
YR 2010
FD 2010-07-13
LK http://hdl.handle.net/10668/415
UL http://hdl.handle.net/10668/415
LA en
DS RISalud
RD Apr 7, 2025