Publication:
Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing.

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Date

2021-07-13

Authors

Melguizo-Rodriguez, Lucia
de Luna-Bertos, Elvira
Ramos-Torrecillas, Javier
Illescas-Montesa, Rebeca
Costela-Ruiz, Victor Javier
Garcia-Martinez, Olga

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MDPI AG
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Abstract

The treatment of tissue damage produced by physical, chemical, or mechanical agents involves considerable direct and indirect costs to health care systems. Wound healing involves a series of molecular and cellular events aimed at repairing the defect in tissue integrity. These events can be favored by various natural agents, including the polyphenols in extra virgin olive oil (EVOO). The objective of this study was to review data on the potential effects of different phenolic compounds that can also be found in EVOO on wound healing and closure. Results of in vitro and animal studies demonstrate that polyphenols from different plant species, also present in EVOO, participate in different aspects of wound healing, accelerating this process through their anti-inflammatory, antioxidant, and antimicrobial properties and their stimulation of angiogenic activities required for granulation tissue formation and wound re-epithelialization. These results indicate the potential usefulness of EVOO phenolic compounds for wound treatment, either alone or in combination with other therapies. Human studies are warranted to verify this proposition.

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MeSH Terms

Humans
Animals
Polyphenols
Olive Oil
Antioxidants
Re-Epithelialization
Phenols
Anti-Infective Agents
Anti-Inflammatory Agents
Delivery of Health Care

DeCS Terms

Aceite de oliva
Animales
Antiinfecciosos
Antiinflamatorios
Antioxidantes
Atención a la salud
Fenoles
Humanos
Polifenoles
Repitelización

CIE Terms

Keywords

extra virgin olive oil, phenolic compounds, tissue regeneration, wound healing

Citation

Melguizo-Rodríguez L, de Luna-Bertos E, Ramos-Torrecillas J, Illescas-Montesa R, Costela-Ruiz VJ, García-Martínez O. Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing. Foods. 2021 Jul 15;10(7):1642.