Publication: DBP rs7041 and DHCR7 rs3829251 are Linked to CD4+ Recovery in HIV Patients on Antiretroviral Therapy.
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2022-01-18
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Resino, Salvador
Jiménez-Sousa, María Ángeles
Blanco, Julià
Pacheco, Yolanda M
Del Romero, Jorge
Peraire, Joaquim
Virseda-Berdices, Ana
Muñoz-Gómez, María José
Galera-Peñaranda, Carlos
García-Fraile, Lucio Jesus
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Abstract
Background: The lack of the recovery of CD4+ T-cells (CD4+ recovery) among immunodeficiency virus (HIV)-infected patients on antiretroviral therapy (ART) is not well known. We aimed to analyze the association between single nucleotide polymorphisms (SNPs) underlying vitamin D metabolism and the CD4+ recovery in naïve HIV-infected patients who started ART with low baseline CD4+. Methods: We conducted a retrospective study in 411 naïve individuals with plasma HIV load >200 copies/mL and CD4+ 200 copies/mL and CD4+
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CD4+ T cells, DBP, DHCR7, HIV, SNP, antiretroviral therapy, immune reconstitution