RT Journal Article T1 DBP rs7041 and DHCR7 rs3829251 are Linked to CD4+ Recovery in HIV Patients on Antiretroviral Therapy. A1 Resino, Salvador A1 Jimenez-Sousa, Maria Angeles A1 Blanco, Julia A1 Pacheco, Yolanda M A1 Del-Romero, Jorge A1 Peraire, Joaquim A1 Virseda-Berdices, Ana A1 Muñoz-Gomez, Maria Jose A1 Galera-Peñaranda, Carlos A1 Garcia-Fraile, Lucio Jesus A1 Benito, Jose M A1 Rallon, Norma K1 CD4+ T cells K1 DBP K1 DHCR7 K1 HIV K1 SNP K1 antiretroviral therapy K1 immune reconstitution AB The lack of the recovery of CD4+ T-cells (CD4+ recovery) among immunodeficiency virus ( HIV )-infected patients on antiretroviral therapy ( ART ) is not well known. We aimed to analyze the association between single nucleotide polymorphisms ( SNPs ) underlying vitamin D metabolism and the CD4+ recovery in naïve HIV -infected patients who started ART with low baseline CD4+.We conducted a retrospective study in 411 naïve individuals with plasma HIV load >200 copies/mL and CD4+ <200 cells /mm3. During 24 months of follow-up, all patients had plasma HIV load <50 copies/mL. DNA genotyping was performed using the Sequenom MassARRAY platform. The outcome variable was the change in CD4+ during the study.Results: CD4+ recovery was higher in patients carrying DBP rs7041 AA genotype (AA versus CC/AC) and DHCR7 rs3829251 AA genotype (AA versus GG/AG) (p-value < 0.05). DBP rs7041 AA genotype was linked to increase in CD4+ (adjusted arithmetic mean ratio (aAMR) = 1.22; q-value = 0.011), increase in CD4+ ≥P75th [adjusted odds ratio (aOR) = 2.31; q-value = 0.005], slope of CD4+ recovery (aAMR = 1.25; q-value = 0.008), slope of CD4+ recovery ≥ P75th (aOR = 2.55; q-value = 0.005) and achievement of CD4+ ≥500 cells /mm3 (aOR = 1.89; q-value = 0.023). Besides, DHCR7 rs3829251 AA genotype was related to increase in CD4+ (aAMR = 1.43; q-value = 0.031), increase in CD4+ ≥P75th (aOR = 3.92; q-value = 0.030), slope of CD4+ recovery (aAMR = 1.40; q-value = 0.036), slope of CD4+ recovery ≥ P75th (aOR = 3.42; q-value = 0.031) and achievement of CD4+ ≥500 cells /mm3 (aOR = 5.68; q-value = 0.015). In summary, DHCR7 rs3829251 and DBP rs7041 polymorphisms were associated with CD4+ recovery in HIV -infected patients who started cART with low CD4+ T-cell counts PB Frontiers Research Foundation SN 1663-9812 YR 2022 FD 2022-01-18 LK http://hdl.handle.net/10668/20699 UL http://hdl.handle.net/10668/20699 LA en NO Resino S, Jiménez-Sousa MÁ, Blanco J, Pacheco YM, Del Romero J, Peraire J, et al. DBP rs7041 and DHCR7 rs3829251 are Linked to CD4+ Recovery in HIV Patients on Antiretroviral Therapy. Front Pharmacol. 2022 Jan 18;12:773848. DS RISalud RD Aug 6, 2025