Publication:
Relative Handgrip Strength as Marker of Cardiometabolic Risk in Women with Systemic Lupus Erythematosus.

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Date

2021-04-27

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Sola-Rodríguez, Sergio
Vargas-Hitos, José Antonio
Gavilán-Carrera, Blanca
Rosales-Castillo, Antonio
Sabio, José Mario
Hernández-Martínez, Alba
Martínez-Rosales, Elena
Ortego-Centeno, Norberto
Soriano-Maldonado, Alberto

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Abstract

This study aimed to examine the association of relative handgrip strength (rHGS) with cardiometabolic disease risk factors in women with systemic lupus erythematosus (SLE). Seventy-seven women with SLE (mean age 43.2, SD 13.8) and clinical stability during the previous six months were included. Handgrip strength was assessed with a digital dynamometer and rHGS was defined as absolute handgrip strength (aHGS) divided by body mass index (BMI). We measured blood pressure, markers of lipid and glucose metabolism, inflammation (high sensitivity C-reactive protein [hs-CRP]), arterial stiffness (pulse wave velocity [PWV]), and renal function. A clustered cardiometabolic risk index (z-score) was computed. Pearson's bivariate correlations revealed that higher rHGS was associated with lower systolic blood pressure (SBP), triglycerides, hs-CRP, PWV, and lower clustered cardiometabolic risk (rrange = from -0.43 to -0.23; all p The findings suggest that higher rHGS is significantly associated with lower cardiometabolic risk in women with SLE.

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Adult
Cardiovascular Diseases
Cross-Sectional Studies
Female
Hand Strength
Humans
Lupus Erythematosus, Systemic
Pulse Wave Analysis
Risk Factors

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Keywords

autoimmune disease, body mass index, cardiovascular disease, cardiovascular risk, lupus, metabolism, muscle strength, risk factors

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