Publication:
Surveillance of Drug-Resistant Tuberculosis in Spain (2001-2015).

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dc.contributor.authorGutiérrez-Aroca, Juan Bautista
dc.contributor.authorRuiz, Pilar
dc.contributor.authorVaquero, Manuel
dc.contributor.authorCausse, Manuel
dc.contributor.authorCasal, Manuel
dc.date.accessioned2023-01-25T10:05:55Z
dc.date.available2023-01-25T10:05:55Z
dc.date.issued2018-04-02
dc.description.abstractMultidrug-resistant tuberculosis (MDR-TB) is a cause of increasing concern. This study investigated first-line anti-TB drug resistance in Mycobacterium tuberculosis strains submitted to the Tuberculosis Reference Center in Córdoba (Spain) between 2001 and 2015. A total of 1,207 cultures were tested against first-line drugs using the BACTEC MGIT 960 system. Resistance to first-line drugs was detected in 207 strains (17.2%), the greatest resistance being found in INH (5.3%) followed by streptomycin (3%), pyrazinamide (2.2%), rifampicin (1%), and ethambutol (0.2%). A total of 1.9% of strains were MDR-TB. Six strains displayed resistance to four drugs, and three strains to five drugs. In view of resistance observed, careful surveillance of drug resistance is recommended.
dc.identifier.doi10.1089/mdr.2017.0353
dc.identifier.essn1931-8448
dc.identifier.pmid29608388
dc.identifier.unpaywallURLhttp://helvia.uco.es/xmlui/bitstream/10396/17611/1/aroca.pdf
dc.identifier.urihttp://hdl.handle.net/10668/12296
dc.issue.number6
dc.journal.titleMicrobial drug resistance (Larchmont, N.Y.)
dc.journal.titleabbreviationMicrob Drug Resist
dc.language.isoen
dc.organizationHospital Universitario Reina Sofía
dc.page.number839-843
dc.pubmedtypeJournal Article
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectmycobacterium
dc.subjectresistance
dc.subjecttuberculosis
dc.subject.meshAntitubercular Agents
dc.subject.meshCross-Sectional Studies
dc.subject.meshDrug Resistance, Multiple, Bacterial
dc.subject.meshHumans
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshMycobacterium tuberculosis
dc.subject.meshSpain
dc.subject.meshTuberculosis, Multidrug-Resistant
dc.subject.meshTuberculosis, Pulmonary
dc.titleSurveillance of Drug-Resistant Tuberculosis in Spain (2001-2015).
dc.typeresearch article
dc.type.hasVersionSMUR
dc.volume.number24
dspace.entity.typePublication

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