Publication: Surveillance of Drug-Resistant Tuberculosis in Spain (2001-2015).
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Date
2018-04-02
Authors
Gutiérrez-Aroca, Juan Bautista
Ruiz, Pilar
Vaquero, Manuel
Causse, Manuel
Casal, Manuel
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Abstract
Multidrug-resistant tuberculosis (MDR-TB) is a cause of increasing concern. This study investigated first-line anti-TB drug resistance in Mycobacterium tuberculosis strains submitted to the Tuberculosis Reference Center in Córdoba (Spain) between 2001 and 2015. A total of 1,207 cultures were tested against first-line drugs using the BACTEC MGIT 960 system. Resistance to first-line drugs was detected in 207 strains (17.2%), the greatest resistance being found in INH (5.3%) followed by streptomycin (3%), pyrazinamide (2.2%), rifampicin (1%), and ethambutol (0.2%). A total of 1.9% of strains were MDR-TB. Six strains displayed resistance to four drugs, and three strains to five drugs. In view of resistance observed, careful surveillance of drug resistance is recommended.
Description
MeSH Terms
Antitubercular Agents
Cross-Sectional Studies
Drug Resistance, Multiple, Bacterial
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Spain
Tuberculosis, Multidrug-Resistant
Tuberculosis, Pulmonary
Cross-Sectional Studies
Drug Resistance, Multiple, Bacterial
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Spain
Tuberculosis, Multidrug-Resistant
Tuberculosis, Pulmonary
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CIE Terms
Keywords
mycobacterium, resistance, tuberculosis