Publication:
Surveillance of Drug-Resistant Tuberculosis in Spain (2001-2015).

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2018-04-02

Authors

Gutiérrez-Aroca, Juan Bautista
Ruiz, Pilar
Vaquero, Manuel
Causse, Manuel
Casal, Manuel

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Abstract

Multidrug-resistant tuberculosis (MDR-TB) is a cause of increasing concern. This study investigated first-line anti-TB drug resistance in Mycobacterium tuberculosis strains submitted to the Tuberculosis Reference Center in Córdoba (Spain) between 2001 and 2015. A total of 1,207 cultures were tested against first-line drugs using the BACTEC MGIT 960 system. Resistance to first-line drugs was detected in 207 strains (17.2%), the greatest resistance being found in INH (5.3%) followed by streptomycin (3%), pyrazinamide (2.2%), rifampicin (1%), and ethambutol (0.2%). A total of 1.9% of strains were MDR-TB. Six strains displayed resistance to four drugs, and three strains to five drugs. In view of resistance observed, careful surveillance of drug resistance is recommended.

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Antitubercular Agents
Cross-Sectional Studies
Drug Resistance, Multiple, Bacterial
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Spain
Tuberculosis, Multidrug-Resistant
Tuberculosis, Pulmonary

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Keywords

mycobacterium, resistance, tuberculosis

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