Children with acute food protein-induced enterocolitis syndrome from Spain and Italy usually tolerate all other food groups.

Abstract

Acute food protein-induced enterocolitis syndrome (‘FPIES’) is a potentially severe type of non-IgE-mediated food allergy affecting mainly infants, usually when foods are introduced. Acute FPIES triggered by multiple unrelated foods (‘multiple food FPIES’) has been reported in up to two-thirds of patients, particularly in the USA. FPIES reactions are often traumatic experiences for parents, and weaning leads to significant anxiety, as there is no test to identify safe new foods. This has led to complex weaning recommendations in children with FPIES in an attempt to support parents. However, evidence suggests that multiple food FPIES is rare in other regions, such as Southern Europe, which questions the applicability of such weaning advice in this population. Studies including a detailed dietary history in children with FPIES are lacking.