Publication: Evaluation of the Bioavailability and Metabolism of Nitroderivatives of Hydroxytyrosol Using Caco-2 and HepG2 Human Cell Models.
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2016-03-10
Authors
Gallardo, Elena
Sarria, Beatriz
Espartero, José Luis
Gonzalez Correa, José Antonio
Bravo-Clemente, Laura
Mateos, Raquel
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Abstract
Considering that nitrocatechols present putative effects against Parkinson's disease, the absorption and metabolism of nitroderivatives of hydroxytyrosol (HT) were assessed using human cell model systems. The test compounds nitrohydroxytyrosol (NO2HT), nitrohydroxytyrosyl acetate (NO2HT-A), and ethyl nitrohydroxytyrosyl ether (NO2HT-E) were efficiently transferred across human Caco-2 cell monolayers as an intestinal barrier model, NO2HT-A and NO2HT-E being better (p
Description
MeSH Terms
Biological Availability
Caco-2 Cells
Hep G2 Cells
Humans
Hydrolysis
Intestinal Mucosa
Liver
Models, Biological
Nitro Compounds
Phenylethyl Alcohol
Caco-2 Cells
Hep G2 Cells
Humans
Hydrolysis
Intestinal Mucosa
Liver
Models, Biological
Nitro Compounds
Phenylethyl Alcohol
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CIE Terms
Keywords
Parkinson’s disease, bioavailability, hydroxytyrosol, metabolism, nitrocatechols