RT Journal Article
T1 Evaluation of the Bioavailability and Metabolism of Nitroderivatives of Hydroxytyrosol Using Caco-2 and HepG2 Human Cell Models.
A1 Gallardo, Elena
A1 Sarria, Beatriz
A1 Espartero, José Luis
A1 Gonzalez Correa, José Antonio
A1 Bravo-Clemente, Laura
A1 Mateos, Raquel
K1 Parkinson’s disease
K1 bioavailability
K1 hydroxytyrosol
K1 metabolism
K1 nitrocatechols
AB Considering that nitrocatechols present putative effects against Parkinson's disease, the absorption and metabolism of nitroderivatives of hydroxytyrosol (HT) were assessed using human cell model systems. The test compounds nitrohydroxytyrosol (NO2HT), nitrohydroxytyrosyl acetate (NO2HT-A), and ethyl nitrohydroxytyrosyl ether (NO2HT-E) were efficiently transferred across human Caco-2 cell monolayers as an intestinal barrier model, NO2HT-A and NO2HT-E being better (p
YR 2016
FD 2016-03-10
LK http://hdl.handle.net/10668/9867
UL http://hdl.handle.net/10668/9867
LA en
DS RISalud
RD Apr 6, 2025