Publication:
Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats.

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Date

2018-04-10

Authors

Paredes, M Dolores
Romecin, Paola
Atucha, Noemi M
O'Valle, Francisco
Castillo, Julian
Ortiz, M Clara
Garcia-Estañ, Joaquin

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MDPI AG
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Abstract

we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks. L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts, hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these treatments, reducing the end-organ vascular damage. the flavonoids included in this study, specially apigenin, may be used as functional food ingredients with potential therapeutic benefit in arterial hypertension.

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MeSH Terms

Animals
Antihypertensive Agents
Apigenin
Flavonoids
Hypertension
Kidney
Male
NG-Nitroarginine Methyl Ester
Plant Extracts
Random Allocation
Rats
Rats, Sprague-Dawley

DeCS Terms

Animales
Antihipertensivos
Apigenina
Distribución aleatoria
Extractos vegetales
Flavonoides
Hipertensión
NG-Nitroarginina Metil Éster
Ratas
Ratas Sprague-Dawley
Riñón

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Keywords

acetylcholine, flavonoids, heart, kidney, nitric oxide, phenylephrine, sodium balance

Citation

Paredes MD, Romecín P, Atucha NM, O'Valle F, Castillo J, Ortiz MC, et al. Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats. Nutrients. 2018 Apr 13;10(4):484.