RT Journal Article
T1 Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats.
A1 Paredes, M Dolores
A1 Romecin, Paola
A1 Atucha, Noemi M
A1 O'Valle, Francisco
A1 Castillo, Julian
A1 Ortiz, M Clara
A1 Garcia-Estañ, Joaquin
K1 acetylcholine
K1 flavonoids
K1 heart
K1 kidney
K1 nitric oxide
K1 phenylephrine
K1 sodium balance
AB we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks. L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts, hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these treatments, reducing the end-organ vascular damage. the flavonoids included in this study, specially apigenin, may be used as functional food ingredients with potential therapeutic benefit in arterial hypertension.
PB MDPI AG
YR 2018
FD 2018-04-10
LK http://hdl.handle.net/10668/12343
UL http://hdl.handle.net/10668/12343
LA en
NO Paredes MD, Romecín P, Atucha NM, O'Valle F, Castillo J, Ortiz MC, et al. Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats. Nutrients. 2018 Apr 13;10(4):484.
NO his report was supported by a grant from the National Spanish R&D Program CENIT of the Spanish Ministry of Science and Technology denominated “Industrial research diets and food with specific features for the elderly”, CEN-20091006; Acronym: SENIFOOD. We have not received funds for covering the costs to publish in open access. We acknowledge the assistance of Justin Davis with the English language.
DS RISalud
RD Apr 18, 2025