Publication: Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases.
Loading...
Identifiers
Date
2019-10-02
Authors
Ruiz-Ojeda, Francisco Javier
Méndez-Gutiérrez, Andrea
Aguilera, Concepción María
Plaza-Díaz, Julio
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The extracellular matrix (ECM) is a network of different proteins and proteoglycans that controls differentiation, migration, repair, survival, and development, and it seems that its remodeling is required for healthy adipose tissue expansion. Obesity drives an excessive lipid accumulation in adipocytes, which provokes immune cells infiltration, fibrosis (an excess of deposition of ECM components such as collagens, elastin, and fibronectin) and inflammation, considered a consequence of local hypoxia, and ultimately insulin resistance. To understand the mechanism of this process is a challenge to treat the metabolic diseases. This review is focused at identifying the putative role of ECM in adipose tissue, describing its structure and components, its main tissue receptors, and how it is affected in obesity, and subsequently the importance of an appropriate ECM remodeling in adipose tissue expansion to prevent metabolic diseases.
Description
MeSH Terms
Adipose Tissue
Animals
Biomarkers
Extracellular Matrix
Humans
Insulin Resistance
Integrins
Metabolic Diseases
Obesity
Animals
Biomarkers
Extracellular Matrix
Humans
Insulin Resistance
Integrins
Metabolic Diseases
Obesity
DeCS Terms
CIE Terms
Keywords
adipose tissue, extracellular matrix, insulin resistance, obesity