RT Journal Article
T1 Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases.
A1 Ruiz-Ojeda, Francisco Javier
A1 Méndez-Gutiérrez, Andrea
A1 Aguilera, Concepción María
A1 Plaza-Díaz, Julio
K1 adipose tissue
K1 extracellular matrix
K1 insulin resistance
K1 obesity
AB The extracellular matrix (ECM) is a network of different proteins and proteoglycans that controls differentiation, migration, repair, survival, and development, and it seems that its remodeling is required for healthy adipose tissue expansion. Obesity drives an excessive lipid accumulation in adipocytes, which provokes immune cells infiltration, fibrosis (an excess of deposition of ECM components such as collagens, elastin, and fibronectin) and inflammation, considered a consequence of local hypoxia, and ultimately insulin resistance. To understand the mechanism of this process is a challenge to treat the metabolic diseases. This review is focused at identifying the putative role of ECM in adipose tissue, describing its structure and components, its main tissue receptors, and how it is affected in obesity, and subsequently the importance of an appropriate ECM remodeling in adipose tissue expansion to prevent metabolic diseases.
YR 2019
FD 2019-10-02
LK http://hdl.handle.net/10668/14581
UL http://hdl.handle.net/10668/14581
LA en
DS RISalud
RD Apr 7, 2025