Publication: Lactobacillus reuteri V3401 Reduces Inflammatory Biomarkers and Modifies the Gastrointestinal Microbiome in Adults with Metabolic Syndrome: The PROSIR Study.
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Date
2019-07-31
Authors
Tenorio-Jiménez, Carmen
Martínez-Ramírez, María José
Del Castillo-Codes, Isabel
Arraiza-Irigoyen, Carmen
Tercero-Lozano, Mercedes
Camacho, José
Chueca, Natalia
García, Federico
Olza, Josune
Plaza-Díaz, Julio
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Abstract
Previous studies have reported that probiotics may improve clinical and inflammatory parameters in patients with obesity and metabolic syndrome (MetS). Lactobacillus (L.) reuteri V3401 has shown promising results on the components of MetS in animal studies. We aimed to evaluate the effects of L. reuteri V3401 together with healthy lifestyle recommendations on adult patients with MetS. We carried out a randomized, crossover, placebo-controlled, single-center trial in which we included 53 adult patients newly diagnosed with MetS. Patients were block randomly allocated by body mass index (BMI) and sex to receive a capsule containing either the probiotic L. reuteri V3401 (5 × 109 colony-forming units) or a placebo once daily for 12 weeks. Anthropometric variables, biochemical and inflammatory biomarkers, as well as the gastrointestinal microbiome composition were determined. There were no differences between groups in the clinical characteristics of MetS. However, we found that interleukin-6 (IL-6) and soluble vascular cell adhesion molecule 1 (sVCAM-1) diminished by effect of the treatment with L. reuteri V3401. Analysis of the gastrointestinal microbiome revealed a rise in the proportion of Verrucomicrobia. Consumption of L. reuteri V3401 improved selected inflammatory parameters and modified the gastrointestinal microbiome. Further studies are needed to ascertain additional beneficial effects of other probiotic strains in MetS as well as the mechanisms by which such effects are exerted.
Description
MeSH Terms
Adult
Biomarkers
Cross-Over Studies
Double-Blind Method
Female
Gastrointestinal Microbiome
Humans
Inflammation
Limosilactobacillus reuteri
Male
Metabolic Syndrome
Probiotics
Biomarkers
Cross-Over Studies
Double-Blind Method
Female
Gastrointestinal Microbiome
Humans
Inflammation
Limosilactobacillus reuteri
Male
Metabolic Syndrome
Probiotics
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Keywords
Lactobacillus reuteri V3401, gastrointestinal microbiome, metabolic syndrome, obesity, probiotics