RT Journal Article
T1 Lactobacillus reuteri V3401 Reduces Inflammatory Biomarkers and Modifies the Gastrointestinal Microbiome in Adults with Metabolic Syndrome: The PROSIR Study.
A1 Tenorio-Jiménez, Carmen
A1 Martínez-Ramírez, María José
A1 Del Castillo-Codes, Isabel
A1 Arraiza-Irigoyen, Carmen
A1 Tercero-Lozano, Mercedes
A1 Camacho, José
A1 Chueca, Natalia
A1 García, Federico
A1 Olza, Josune
A1 Plaza-Díaz, Julio
A1 Fontana, Luis
A1 Olivares, Mónica
A1 Gil, Ángel
A1 Gómez-Llorente, Carolina
K1 Lactobacillus reuteri V3401
K1 gastrointestinal microbiome
K1 metabolic syndrome
K1 obesity
K1 probiotics
AB Previous studies have reported that probiotics may improve clinical and inflammatory parameters in patients with obesity and metabolic syndrome (MetS). Lactobacillus (L.) reuteri V3401 has shown promising results on the components of MetS in animal studies. We aimed to evaluate the effects of L. reuteri V3401 together with healthy lifestyle recommendations on adult patients with MetS. We carried out a randomized, crossover, placebo-controlled, single-center trial in which we included 53 adult patients newly diagnosed with MetS. Patients were block randomly allocated by body mass index (BMI) and sex to receive a capsule containing either the probiotic L. reuteri V3401 (5 × 109 colony-forming units) or a placebo once daily for 12 weeks. Anthropometric variables, biochemical and inflammatory biomarkers, as well as the gastrointestinal microbiome composition were determined. There were no differences between groups in the clinical characteristics of MetS. However, we found that interleukin-6 (IL-6) and soluble vascular cell adhesion molecule 1 (sVCAM-1) diminished by effect of the treatment with L. reuteri V3401. Analysis of the gastrointestinal microbiome revealed a rise in the proportion of Verrucomicrobia. Consumption of L. reuteri V3401 improved selected inflammatory parameters and modified the gastrointestinal microbiome. Further studies are needed to ascertain additional beneficial effects of other probiotic strains in MetS as well as the mechanisms by which such effects are exerted.
YR 2019
FD 2019-07-31
LK http://hdl.handle.net/10668/14352
UL http://hdl.handle.net/10668/14352
LA en
DS RISalud
RD Apr 9, 2025