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Off-label uses of anti-TNF therapy in three frequent disorders: Behçet's disease, sarcoidosis, and noninfectious uveitis.

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dc.contributor.authorSánchez-Cano, Daniel
dc.contributor.authorCallejas-Rubio, José Luis
dc.contributor.authorRuiz-Villaverde, Ricardo
dc.contributor.authorRíos-Fernández, Raquel
dc.contributor.authorOrtego-Centeno, Norberto
dc.contributor.authoraffiliation[Sánchez-Cano,D] Internal Medicine Department, Hospital Santa Ana, Motril, Spain. [Callejas-Rubio,JL; Ríos-Fernández,R; Ortego-Centeno,N] Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario San Cecilio, Granada, Spain. [Ruiz-Villaverde,R] Dermatology Department, Complejo Hospitalario Ciudad de Jaén, Spain.es
dc.date.accessioned2015-08-11T09:08:18Z
dc.date.available2015-08-11T09:08:18Z
dc.date.issued2013-08
dc.descriptionJournal Article; Review;es
dc.description.abstractTumoral necrosis factor α plays a central role in both the inflammatory response and that of the immune system. Thus, its blockade with the so-called anti-TNF agents (infliximab, etanercept, adalimumab, certolizumab pegol, and golimumab) has turned into the most important tool in the management of a variety of disorders, such as rheumatoid arthritis, spondyloarthropatties, inflammatory bowel disease, and psoriasis. Nonetheless, theoretically, some other autoimmune disorders may benefit from these agents. Our aim is to review these off-label uses of anti-TNF blockers in three common conditions: Behçet's disease, sarcoidosis, and noninfectious uveitis. Due to the insufficient number of adequate clinical trials and consequently to their lower prevalence compared to other immune disorders, this review is mainly based on case reports and case series.es
dc.description.versionYeses
dc.identifier.citationSánchez-Cano D, Callejas-Rubio JL, Ruiz-Villaverde R, Ríos-Fernández R, Ortego-Centeno N. Off-label uses of anti-TNF therapy in three frequent disorders: Behçet's disease, sarcoidosis, and noninfectious uveitis. Mediators Inflamm. 2013, 2013:286857es
dc.identifier.doi10.1155/2013/286857
dc.identifier.essn1466-1861
dc.identifier.issn0962-9351
dc.identifier.pmcPMC3747407
dc.identifier.pmid23983404
dc.identifier.urihttp://hdl.handle.net/10668/1961
dc.journal.titleMediators of Inflammation
dc.language.isoen
dc.organizationAGS Sur de Granada
dc.publisherHindawi Publishing Corporationes
dc.relation.publisherversionhttp://www.hindawi.com/journals/mi/2013/286857/es
dc.rights.accessRightsopen access
dc.subjectAnticuerpos monoclonaleses
dc.subjectAnticuerpos monoclonales humanizadoses
dc.subjectFragmentos Fab de inmunoglobulinases
dc.subjectInmunoglobulina Ges
dc.subjectGlicoles de polietilenoes
dc.subjectReceptores del factor de necrosis tumorales
dc.subjectFactor de necrosis tumoral alfaes
dc.subjectAntiinflamatorioses
dc.subjectUveítises
dc.subjectSarcoidosis pulmonares
dc.subjectUso fuera de lo indicadoes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agentses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Monoclonales
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Monoclonal::Antibodies, Monoclonal, Humanizedes
dc.subject.meshMedical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseaseses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Globulins::Serum Globulins::Immunoglobulins::Immunoglobulin Fragments::Immunoglobulin Fab Fragmentses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin Ges
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammationes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Prescriptions::Off-Label Usees
dc.subject.meshMedical Subject Headings::Technology, Industry, Agriculture::Technology, Industry, and Agriculture::Manufactured Materials::Biomedical and Dental Materials::Polymers::Polyethylene Glycolses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Cytokine::Receptors, Tumor Necrosis Factores
dc.subject.meshMedical Subject Headings::Diseases::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Interstitial::Sarcoidosis, Pulmonaryes
dc.subject.meshTreatment Outcomees
dc.subject.meshMedical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Lymphatic Diseases::Lymphoproliferative Disorders::Sarcoidosises
dc.subject.meshMedical Subject Headings::Diseases::Eye Diseases::Uveal Diseases::Uveitises
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses
dc.titleOff-label uses of anti-TNF therapy in three frequent disorders: Behçet's disease, sarcoidosis, and noninfectious uveitis.es
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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