SAS - Hospital Santa Ana
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Item Increased infections by herpes simplex virus type 1 and polymicrobials of the genital tract, in the general population of a Spanish middle city(Sociedad espanola quimioterapia, 2021-08-01) Perez-Torralba, Concepcion; Ruiz-Olivares, Maria; Sanbonmatsu-Gamez, Sara; Exposito-Ruiz, Manuela; Maria Navarro-Mari, Jose; Gutierrez-Fernandez, Jose; [Perez-Torralba, Concepcion] Univ Granada, Fac Med, Dept Microbiol, Inst Invest Biosanitaria Granada, Granada, Spain; [Gutierrez-Fernandez, Jose] Univ Granada, Fac Med, Dept Microbiol, Inst Invest Biosanitaria Granada, Granada, Spain; [Ruiz-Olivares, Maria] Hosp Santa Ana, Dept Obstet & Ginecol, Granada, Spain; [Sanbonmatsu-Gamez, Sara] Hosp Univ Virgen de las Nieves, Dept Microbiol, Inst Invest Biosanitaria Granada, Granada, Spain; [Maria Navarro-Mari, Jose] Hosp Univ Virgen de las Nieves, Dept Microbiol, Inst Invest Biosanitaria Granada, Granada, Spain; [Gutierrez-Fernandez, Jose] Hosp Univ Virgen de las Nieves, Dept Microbiol, Inst Invest Biosanitaria Granada, Granada, Spain; [Exposito-Ruiz, Manuela] Hosp Univ Virgen de las Nieves, Fdn Invest Biosanitaria Andalucia Oriental FIBAO, Granada, SpainIntroduction. Infections by genitopathogens are a frequent reason for consultation in Primary Health Care and in the specialties of Infectious Diseases, Urology, Gynecology, and Dermatology. The most common causes are opportunistic microorganisms and responsible for sexually transmitted infections associated with unprotected sex. The objective is to determine the microorganisms that cause these infections in patients treated at the SAS - Hospital Universitario Virgen de las Nieves in Granada and Neisseria gonorrhoeae susceptibility to antibiotics.Material and methods. A transversal-descriptive and retrospective study was carried out, which included the results issued, between January 2018 and December 2019, in the Microbiology Laboratory from all the episodes studied using standardized working procedures.Results. The most frequently detected microorganisms were Gardnerella vaginalis (23.81%) followed by Candida spp. (20.9%), especially in females, and N. gonorrhoeae (11.36%) and Ureaplasma urealyticum (11.99%), in males. Many times, they were presented in combination. Regarding herpes simplex viruses, infection by both species had a similar prevalence (50%) in males, while type 1 was more prevalent (76.52%) in females. The most active antibiotics against N. gonorrhoeae were cefotaxime (98%) and cefixime (100%). Tetracycline (39.02%) a poorly active antibiotic.Conclusions. The most frequent pathogens corresponded to those that usually caused infections in females, although N. gonorrhoeae was the most frequent in males and mixed infections are not an accidental finding. HSV-1 infections were more frequent than HSV-2, confirming the trend of a change in the epidemiology of genital herpes.Item [Increased infections by herpes simplex virus type 1 and polymicrobials of the genital tract, in the general population of a Spanish middle city].(2021-04-22) Pérez-Torralba, C; Ruiz-Olivares, M; Sanbonmatsu-Gámez, S; Expósito-Ruíz, M; Navarro-Marí, J M; Gutiérrez-Fernández, JInfections by genitopathogens are a frequent reason for consultation in Primary Health Care and in the specialties of Infectious Diseases, Urology, Gynecology, and Dermatology. The most common causes are opportunistic microorganisms and responsible for sexually transmitted infections associated with unprotected sex. The objective is to determine the microorganisms that cause these infections in patients treated at the SAS - Hospital Universitario Virgen de las Nieves in Granada and Neisseria gonorrhoeae susceptibility to antibiotics. A transversal-descriptive and retrospective study was carried out, which included the results issued, between January 2018 and December 2019, in the Microbiology Laboratory from all the episodes studied using standardized working procedures. The most frequently detected microorganisms were Gardnerella vaginalis (23.81%) followed by Candida spp. (20.9%), especially in females, and N. gonorrhoeae (11.36%) and Ureaplasma urealyticum (11.99%), in males. Many times, they were presented in combination. Regarding herpes simplex viruses, infection by both species had a similar prevalence (50%) in males, while type 1 was more prevalent (76.52%) in females. The most active antibiotics against N. gonorrhoeae were cefotaxime (98%) and cefixime (100%). Tetracycline (39.02%) a poorly active antibiotic. The most frequent pathogens corresponded to those that usually caused infections in females, although N. gonorrhoeae was the most frequent in males and mixed infections are not an accidental finding. HSV-1 infections were more frequent than HSV-2, confirming the trend of a change in the epidemiology of genital herpes.Item ASSOCIATION OF ENDOTHELIN-1 WITH PULSE WAVE VELOCITY IN SYSTEMIC SCLEROSIS PATIENTS(Bmj publishing group, 2021-06-01) Alvarez de Cienfuegos, A.; Cantero-Nieto, L.; Garcia-Gomez, J. A.; Callejas-Rubio, J. L.; Martin Ibanez, J.; Ortego, N.; [Alvarez de Cienfuegos, A.] Hosp Vega Baja, Dept Rheumatol, Alicante, Spain; [Cantero-Nieto, L.] Hosp Santa Ana, Dept Emergency, Granada, Spain; [Garcia-Gomez, J. A.] Hosp Gen Elche, Infect Dis Unit, Alicante, Spain; [Callejas-Rubio, J. L.] Hosp Univ San Cecilio, Syst Autoimmune Dis Unit, Granada, Spain; [Ortego, N.] Hosp Univ San Cecilio, Syst Autoimmune Dis Unit, Granada, Spain; [Martin Ibanez, J.] IPBLN CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada, SpainItem FIBROBLAST GROWTH FACTOR-23 IS ASSOCIATED WITH HIGH-DENSITY LIPOPROTEIN IN SYSTEMIC SCLEROSIS PATIENTS(Bmj publishing group, 2021-06-01) Alvarez de Cienfuegos, A.; Cantero-Nieto, L.; Garcia-Gomez, J. A.; Rios Fernandez, R.; Martin Ibanez, J.; Gonzalez-Gay, M. A.; Ortego, N.; [Alvarez de Cienfuegos, A.] Hosp Vega Baja, Dept Rheumatol, Alicante, Spain; [Cantero-Nieto, L.] Hosp Santa Ana, Dept Emergency, Granada, Spain; [Garcia-Gomez, J. A.] Hosp Gen Elche, Infect Dis Unit, Alicante, Spain; [Rios Fernandez, R.] Hosp Univ San Cecilio, Syst Autoimmune Dis Unit, Granada, Spain; [Ortego, N.] Hosp Univ San Cecilio, Syst Autoimmune Dis Unit, Granada, Spain; [Martin Ibanez, J.] IPBLN CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada, Spain; [Gonzalez-Gay, M. A.] Univ Cantabria, Sch Med, Santander, SpainItem THE EFFECT OF SMOKING ON ENDOTHELIN-1 IN PATIENTS WITH RHEUMATOID ARTHRITIS(Bmj publishing group, 2019-06-01) Alvarez de Cienfuegos, Antonio; Cantero-Nieto, Lucia; Alberto Garcia-Gomez, Jose; Robledo, Gema; Martin Ibanez, Javier; Rios Fernandez, Raquel; Gonzalez-Gay, Miguel A.; Ortego, Norberto; [Alvarez de Cienfuegos, Antonio] Vega Baja Hosp, Rheumatol, Orihuela, Spain; [Cantero-Nieto, Lucia] Santa Ana Hosp, Granada, Spain; [Alberto Garcia-Gomez, Jose] Hosp Gen Univ Elx, Elche, Spain; [Robledo, Gema] CSIC, IPBLN, Granada, Spain; [Martin Ibanez, Javier] CSIC, IPBLN, Granada, Spain; [Rios Fernandez, Raquel] Hosp Univ San Cecilio, Unit Syst Autoimmune Dis Internal Med, Granada, Spain; [Ortego, Norberto] Hosp Univ San Cecilio, Unit Syst Autoimmune Dis Internal Med, Granada, Spain; [Gonzalez-Gay, Miguel A.] IDIVAL, Santander, SpainItem ASSOCIATION OF HOMOCYSTEINE WITH BONE MINERAL DENSITY IN RHEUMATOID ARTHRITIS PATIENTS(Bmj publishing group, 2019-06-01) Alvarez de Cienfuegos, Antonio; Cantero-Nieto, Lucia; Alberto Garcia-Gomez, Jose; Luis Callejas-Rubio, Jose; Gonzalez-Gay, Miguel A.; Ortego, Norberto; [Alvarez de Cienfuegos, Antonio] Vega Baja Hosp, Rheumatol, Orihuela, Spain; [Cantero-Nieto, Lucia] Santa Ana Hosp, Granada, Spain; [Alberto Garcia-Gomez, Jose] Hosp Gen Univ Elx, Elche, Spain; [Luis Callejas-Rubio, Jose] Hosp Univ San Cecilio, Unit Syst Autoimmune Dis Internal Med, Granada, Spain; [Ortego, Norberto] Hosp Univ San Cecilio, Unit Syst Autoimmune Dis Internal Med, Granada, Spain; [Gonzalez-Gay, Miguel A.] IDIVAL, Santander, SpainItem THE ROLE OF KLOTHO IN RHEUMATOID ARTHRITIS(Bmj publishing group, 2019-06-01) Alvarez de Cienfuegos, Antonio; Cantero-Nieto, Lucia; Alberto Garcia-Gomez, Jose; Robledo, Gema; Sanchez-Cano, Daniel; Martin Ibanez, Javier; Gonzalez-Gay, Miguel A.; Ortego, Norberto; [Alvarez de Cienfuegos, Antonio] Vega Baja Hosp, Rheumatol, Orihuela, Spain; [Cantero-Nieto, Lucia] Santa Ana Hosp, Granada, Spain; [Alberto Garcia-Gomez, Jose] Hosp Gen Univ Elx, Elche, Spain; [Robledo, Gema] CSIC, IPBLN, Granada, Spain; [Martin Ibanez, Javier] CSIC, IPBLN, Granada, Spain; [Sanchez-Cano, Daniel] Hosp Univ San Cecilio, Internal Med, Granada, Spain; [Gonzalez-Gay, Miguel A.] IDIVAL, Santander, Spain; [Ortego, Norberto] Hosp Univ San Cecilio, Unit Syst Autoimmune Dis Internal Med, Granada, SpainItem CIRCULATING FIBROBLAST GROWTH FACTOR-23 IS ASSOCIATED WITH DYSLIPIDEMIA IN RHEUMATOID ARTHRITIS PATIENTS(Bmj publishing group, 2019-06-01) Alvarez de Cienfuegos, Antonio; Cantero-Nieto, Lucia; Alberto Garcia-Gomez, Jose; Robledo, Gema; Trigo, Marta; Martin Ibanez, Javier; Gonzalez-Gay, Miguel A.; Ortego, Norberto; [Alvarez de Cienfuegos, Antonio] Vega Baja Hosp, Rheumatol, Orihuela, Spain; [Cantero-Nieto, Lucia] Santa Ana Hosp, Emergency, Granada, Spain; [Alberto Garcia-Gomez, Jose] Hosp Gen Univ Elx, Elche, Spain; [Robledo, Gema] CSIC, IPBLN, Granada, Spain; [Martin Ibanez, Javier] CSIC, IPBLN, Granada, Spain; [Trigo, Marta] Hosp San Cecilio, Internal Med, Granada, Spain; [Gonzalez-Gay, Miguel A.] IDIVAL, Santander, Spain; [Ortego, Norberto] Hosp Univ San Cecilio, Internal Med, Granada, SpainItem Persons with first episode psychosis have distinct profiles of social cognition and metacognition(Nature portfolio, 2021-12-09) Ferrer-Quintero, M.; Fernandez, D.; Lopez-Carrilero, R.; Birules, I.; Barajas, A.; Lorente-Rovira, E.; Diaz-Cutraro, L.; Verdaguer, M.; Garcia-Mieres, H.; Sevilla-Llewellyn-Jones, J.; Gutierrez-Zotes, A.; Grasa, E.; Pousa, E.; Huerta-Ramos, E.; Pelaez, T.; Barrigon, M. L.; Gonzalez-Higueras, F.; Ruiz-Delgado, I.; Cid, J.; Moritz, S.; Ochoa, S.; Spanish Metacognition Grp; [Ferrer-Quintero, M.] Parc Sanitari St Joan Deu, Barcelona, Spain; [Fernandez, D.] Parc Sanitari St Joan Deu, Barcelona, Spain; [Lopez-Carrilero, R.] Parc Sanitari St Joan Deu, Barcelona, Spain; [Birules, I.] Parc Sanitari St Joan Deu, Barcelona, Spain; [Diaz-Cutraro, L.] Parc Sanitari St Joan Deu, Barcelona, Spain; [Verdaguer, M.] Parc Sanitari St Joan Deu, Barcelona, Spain; [Garcia-Mieres, H.] Parc Sanitari St Joan Deu, Barcelona, Spain; [Huerta-Ramos, E.] Parc Sanitari St Joan Deu, Barcelona, Spain; [Pelaez, T.] Parc Sanitari St Joan Deu, Barcelona, Spain; [Ochoa, S.] Parc Sanitari St Joan Deu, Barcelona, Spain; [Ferrer-Quintero, M.] Univ Barcelona, Dept Psicol Social & Psicol Quantit, Barcelona, Spain; [Birules, I.] Univ Barcelona, Dept Psicol Social & Psicol Quantit, Barcelona, Spain; [Ferrer-Quintero, M.] Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain; [Fernandez, D.] Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain; [Lopez-Carrilero, R.] Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain; [Lorente-Rovira, E.] Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain; [Gutierrez-Zotes, A.] Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain; [Grasa, E.] Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain; [Pousa, E.] Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain; [Huerta-Ramos, E.] Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain; [Pelaez, T.] Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain; [Ochoa, S.] Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain; [Fernandez, D.] Fundacio St Joan Deu, Barcelona, Spain; [Lopez-Carrilero, R.] Fundacio St Joan Deu, Barcelona, Spain; [Fernandez, D.] Univ Politecn Cataluna, Dept Stat & Operat Res, Barcelona, Spain; [Barajas, A.] Univ Autonoma Barcelona, Fac Psicol, Dept Psicol Clin & Salut, Barcelona, Spain; [Barajas, A.] Ctr Higiene Mental Corts, Dept Res, Barcelona, Spain; [Lorente-Rovira, E.] Hosp Clin Univ Valencia, Psychiat Serv, Barcelona, Spain; [Sevilla-Llewellyn-Jones, J.] Clin San Carlos Hosp, Hlth Res Inst IdISSC, Inst Psychiat & Mental Hlth, Madrid, Spain; [Gutierrez-Zotes, A.] Univ Rovira & Virgili, Inst Invest Sanitaria Pere Virgili IISPV, Hosp Univ Inst Pere Mata, Reus, Spain; [Grasa, E.] Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St Pau, Hosp Santa Creu & St Pau, Dept Psychiat, Barcelona, Spain; [Pousa, E.] Univ Autonoma Barcelona, Inst Invest Biomed St Pau IIB St Pau, Hosp Santa Creu & St Pau, Dept Psychiat, Barcelona, Spain; [Pousa, E.] Univ Autonoma Barcelona, Hosp Univ UAB, Salut Mental Parc Tauli Sabadell Barcelona, Barcelona, Spain; [Pousa, E.] Hosp del Mar, IMIM Hosp del Mar Med Res Inst, Neuropsiquiatria & Add, Barcelona, Spain; [Barrigon, M. L.] IIS Fdn, Jimenez Diaz Hosp Madrid, Dept Psychiat, Madrid, Spain; [Barrigon, M. L.] Area Gest Sanitaria Granada, Psychiat Serv, Granada, Spain; [Gonzalez-Higueras, F.] Comunidad Terapeut Jaen Serv Andaluz Salud, Jaen, Spain; [Ruiz-Delgado, I.] Unidad Salud Mental Comunitaria Malaga Norte, Malaga, Spain; [Cid, J.] Inst Assistencia Sanitaria, IdiBGi, Mental Hlth & Addict Res Grp, Girona, Spain; [Moritz, S.] Univ Med Ctr Hamburg, Dept Psychiat & Psychotherapy, Hamburg, Germany; Instituto de Salud Carlos III, Spanish Government; Fondo Europeo de Desarrollo Regional (FEDER); PERIS call; Progress and Health Foundation of the Andalusian Regional Ministry of Health; Obra Social La Caixa; Obra Social Sant Joan de Deu, BML; Agencia Estatal de Investigacion (AEI, Spain); European Regional Development Fund (FEDER, UE); Marsden; GRBIO; Health Department of CataloniaSubjects with first-episode psychosis experience substantial deficits in social cognition and metacognition. Although previous studies have investigated the role of profiles of individuals in social cognition and metacognition in chronic schizophrenia, profiling subjects with first-episode psychosis in both domains remains to be investigated. We used latent profile analysis to derive profiles of the abilities in 174 persons with first-episode psychosis using the Beck's Cognitive Insight Scale, the Faces Test, the Hinting Task, the Internal, Personal and Situational Attributions Questionnaire, and the Beads Task. Participants received a clinical assessment and a neuropsychological assessment. The best-fitting model was selected according to the Bayesian information criterion (BIC). We assessed the importance of the variables via a classification tree (CART). We derived three dusters with distinct profiles. The first profile (333%) comprised individuals with low social cognition. The second profile (60.9%) comprised individuals that had more proneness to present jumping to conclusions. The third profile (5.7%) presented a heterogeneous profile of metacognitive deficits. Persons with lower social cognition presented worse clinical and neuropsychological features than cluster 2 and cluster 3. Cluster 3 presented significantly worst functioning. Our results suggest that individuals with FEP present distinct profiles that concur with specific clinical, neuropsychological, and functional challenges. Each subgroup may benefit from different interventions.Item Persons with first episode psychosis have distinct profiles of social cognition and metacognition.(2021-12-09) Ferrer-Quintero, M; Fernández, D; López-Carrilero, R; Birulés, I; Barajas, A; Lorente-Rovira, E; Díaz-Cutraro, L; Verdaguer, M; García-Mieres, H; Sevilla-Llewellyn-Jones, J; Gutiérrez-Zotes, A; Grasa, E; Pousa, E; Huerta-Ramos, E; Pélaez, T; Barrigón, M L; González-Higueras, F; Ruiz-Delgado, I; Cid, J; Moritz, S; Spanish Metacognition Group; Ochoa, SSubjects with first-episode psychosis experience substantial deficits in social cognition and metacognition. Although previous studies have investigated the role of profiles of individuals in social cognition and metacognition in chronic schizophrenia, profiling subjects with first-episode psychosis in both domains remains to be investigated. We used latent profile analysis to derive profiles of the abilities in 174 persons with first-episode psychosis using the Beck's Cognitive Insight Scale, the Faces Test, the Hinting Task, the Internal, Personal and Situational Attributions Questionnaire, and the Beads Task. Participants received a clinical assessment and a neuropsychological assessment. The best-fitting model was selected according to the Bayesian information criterion (BIC). We assessed the importance of the variables via a classification tree (CART). We derived three clusters with distinct profiles. The first profile (33.3%) comprised individuals with low social cognition. The second profile (60.9%) comprised individuals that had more proneness to present jumping to conclusions. The third profile (5.7%) presented a heterogeneous profile of metacognitive deficits. Persons with lower social cognition presented worse clinical and neuropsychological features than cluster 2 and cluster 3. Cluster 3 presented significantly worst functioning. Our results suggest that individuals with FEP present distinct profiles that concur with specific clinical, neuropsychological, and functional challenges. Each subgroup may benefit from different interventions.Item Clinical practice guidelines and consensus for the screening of breast cancer: A systematic appraisal of their quality and reporting(Wiley, 2021-12-23) Maes-Carballo, Marta; Mignini, Luciano; Martin-Diaz, Manuel; Bueno-Cavanillas, Aurora; Khan, Khalid Saeed; [Maes-Carballo, Marta] Complexo Hosp Univ Ourense, Breast Canc Unit, Dept Gen Surg, Calle Ramon Puga Noguerol,54, Orense 32005, Spain; [Maes-Carballo, Marta] Hosp Publ Verin, Dept Gen Surg, Orense, Spain; [Maes-Carballo, Marta] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain; [Bueno-Cavanillas, Aurora] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain; [Khan, Khalid Saeed] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain; [Mignini, Luciano] Grp Orono, Unidad Mastol, Rosario, Argentina; [Martin-Diaz, Manuel] Hosp Motril, Dept Gen Surg, Granada, Spain; [Bueno-Cavanillas, Aurora] CIBERESP, CIBER Epidemiol & Publ Hlth, Madrid, Spain; [Khan, Khalid Saeed] CIBERESP, CIBER Epidemiol & Publ Hlth, Madrid, Spain; [Bueno-Cavanillas, Aurora] IBS, Inst Invest Biosanitaria, Granada, Spain; Ministry of Science, Innovation, and University of Granada/Consorcio de Bibliotecas Universitarias de Andalucia (CBUA)Introduction Clinical practice guidelines (CPGs) and consensus statements (CSs) are being promoted to provide high-quality healthcare guidance. This systematic review has assessed the breast cancer (BC) screening CPGs and CSs quality and reporting. Methods A search of bibliographic databases (MEDLINE, Embase, Web of Science, Scopus and CDSR), 12 guideline databases and 51 professional society websites was performed without language restrictions from January 2017 to June 2020, following prospective registration (Prospero no.: CRD42020203807). AGREE II (% of maximum score) and RIGHT (% of total 35 items) appraised quality and reporting individually, extracting data in duplicate; reviewer agreement was 98% and 93%, respectively. Results Forty guidances with median overall quality and reporting 51% (interquartile range [IQR] 39-63) and 48% (IQR 35-65), respectively. Twenty-two (55%) and 20 (50%) did not reach the minimum standards (scoresItem Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses.(2021-10-28) Emerging Risk Factors Collaboration/EPIC-CVD/Vitamin D Studies CollaborationRandomised trials of vitamin D supplementation for cardiovascular disease and all-cause mortality have generally reported null findings. However, generalisability of results to individuals with low vitamin D status is unclear. We aimed to characterise dose-response relationships between 25-hydroxyvitamin D (25[OH]D) concentrations and risk of coronary heart disease, stroke, and all-cause mortality in observational and Mendelian randomisation frameworks. Observational analyses were undertaken using data from 33 prospective studies comprising 500 962 individuals with no known history of coronary heart disease or stroke at baseline. Mendelian randomisation analyses were performed in four population-based cohort studies (UK Biobank, EPIC-CVD, and two Copenhagen population-based studies) comprising 386 406 middle-aged individuals of European ancestries, including 33 546 people who developed coronary heart disease, 18 166 people who had a stroke, and 27 885 people who died. Primary outcomes were coronary heart disease, defined as fatal ischaemic heart disease (International Classification of Diseases 10th revision code I20-I25) or non-fatal myocardial infarction (I21-I23); stroke, defined as any cerebrovascular disease (I60-I69); and all-cause mortality. Observational analyses suggested inverse associations between incident coronary heart disease, stroke, and all-cause mortality outcomes with 25(OH)D concentration at low 25(OH)D concentrations. In population-wide genetic analyses, there were no associations of genetically-predicted 25(OH)D with coronary heart disease, stroke, or all-cause mortality. However, for the participants with vitamin D deficiency (25[OH]D concentration Stratified Mendelian randomisation analyses suggest a causal relationship between 25(OH)D concentrations and mortality for individuals with low vitamin D status. Our findings have implications for the design of vitamin D supplementation trials, and potential disease prevention strategies. British Heart Foundation, Medical Research Council, National Institute for Health Research, Health Data Research UK, Cancer Research UK, and International Agency for Research on Cancer.Item Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study.(2021-01-08) Pun, Brenda T; Badenes, Rafael; Heras La Calle, Gabriel; Orun, Onur M; Chen, Wencong; Raman, Rameela; Simpson, Beata-Gabriela K; Wilson-Linville, Stephanie; Hinojal Olmedillo, Borja; Vallejo de la Cueva, Ana; van der Jagt, Mathieu; Navarro Casado, Rosalía; Leal Sanz, Pilar; Orhun, Günseli; Ferrer Gómez, Carolina; Núñez Vázquez, Karla; Piñeiro Otero, Patricia; Taccone, Fabio Silvio; Gallego Curto, Elena; Caricato, Anselmo; Woien, Hilde; Lacave, Guillaume; O'Neal, Hollis R; Peterson, Sarah J; Brummel, Nathan E; Girard, Timothy D; Ely, E Wesley; Pandharipande, Pratik P; COVID-19 Intensive Care International Study GroupTo date, 750 000 patients with COVID-19 worldwide have required mechanical ventilation and thus are at high risk of acute brain dysfunction (coma and delirium). We aimed to investigate the prevalence of delirium and coma, and risk factors for delirium in critically ill patients with COVID-19, to aid the development of strategies to mitigate delirium and associated sequelae. This multicentre cohort study included 69 adult intensive care units (ICUs), across 14 countries. We included all patients (aged ≥18 years) admitted to participating ICUs with severe acute respiratory syndrome coronavirus 2 infection before April 28, 2020. Patients who were moribund or had life-support measures withdrawn within 24 h of ICU admission, prisoners, patients with pre-existing mental illness, neurodegenerative disorders, congenital or acquired brain damage, hepatic coma, drug overdose, suicide attempt, or those who were blind or deaf were excluded. We collected de-identified data from electronic health records on patient demographics, delirium and coma assessments, and management strategies for a 21-day period. Additional data on ventilator support, ICU length of stay, and vital status was collected for a 28-day period. The primary outcome was to determine the prevalence of delirium and coma and to investigate any associated risk factors associated with development of delirium the next day. We also investigated predictors of number of days alive without delirium or coma. These outcomes were investigated using multivariable regression. Between Jan 20 and April 28, 2020, 4530 patients with COVID-19 were admitted to 69 ICUs, of whom 2088 patients were included in the study cohort. The median age of patients was 64 years (IQR 54 to 71) with a median Simplified Acute Physiology Score (SAPS) II of 40·0 (30·0 to 53·0). 1397 (66·9%) of 2088 patients were invasively mechanically ventilated on the day of ICU admission and 1827 (87·5%) were invasively mechanical ventilated at some point during hospitalisation. Infusion with sedatives while on mechanical ventilation was common: 1337 (64·0%) of 2088 patients were given benzodiazepines for a median of 7·0 days (4·0 to 12·0) and 1481 (70·9%) were given propofol for a median of 7·0 days (4·0 to 11·0). Median Richmond Agitation-Sedation Scale score while on invasive mechanical ventilation was -4 (-5 to -3). 1704 (81·6%) of 2088 patients were comatose for a median of 10·0 days (6·0 to 15·0) and 1147 (54·9%) were delirious for a median of 3·0 days (2·0 to 6·0). Mechanical ventilation, use of restraints, and benzodiazepine, opioid, and vasopressor infusions, and antipsychotics were each associated with a higher risk of delirium the next day (all p≤0·04), whereas family visitation (in person or virtual) was associated with a lower risk of delirium (p Acute brain dysfunction was highly prevalent and prolonged in critically ill patients with COVID-19. Benzodiazepine use and lack of family visitation were identified as modifiable risk factors for delirium, and thus these data present an opportunity to reduce acute brain dysfunction in patients with COVID-19. None. For the French and Spanish translations of the abstract see Supplementary Materials section.Item Inflammatory complications of the pouch, and therapetic requirements after colectomy in patients with ulcerative colitis. Results from the RESERVO Study of GETECCU(Oxford univ press, 2021-05-01) Mesonero Gisnsero, F.; Zabana, Y.; Fernandez-Cloret, A.; Sola, A.; Caballol, B.; Leo, E.; Garcia, M. J.; Bertoletti, F.; Alejandro, M.; Suris, G.; Casis, B.; Ferreiro-Iglesias, R.; Calafat, M.; Jimenez, I.; Miranda-Bautista, J.; Lamuela, L. J.; Fajardo, I.; Torrealba, L.; Najera, R.; Saiz, R. M.; Gonzalez, I.; Vicuna, N.; Garcia-Morales, N.; Gutierrez, A.; Lopez-Garcia, A.; Benitez, J. N.; Rubin de Celix, C.; Tejido, C.; Brunet, E.; Baston, I.; Rodriguez-Lago, I.; Baltar, R.; Huguet, J. M.; Hermida, B.; Caballero-Mateos, A.; Sanchez-Guillen, L.; Bouhmidi, A.; Pajares, B.; Lopez-Sanroman, A.; Barreiro-de Acosta, M.; Young Grp GETECCU RESERVO Stud; [Mesonero Gisnsero, F.] Hosp Univ Ramon y Cajal, Dept Gastroenterol, Madrid, Spain; [Lopez-Sanroman, A.] Hosp Univ Ramon y Cajal, Dept Gastroenterol, Madrid, Spain; [Zabana, Y.] Hosp Univ Mutua Terrassa, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Gastroenterol, Barcelona, Spain; [Fernandez-Cloret, A.] Hosp Clin Barcelona, Gastroenterol, Barcelona, Spain; [Caballol, B.] Hosp Clin Barcelona, Gastroenterol, Barcelona, Spain; [Sola, A.] Hosp Univ Virgen Rocio, Gastroenterol, Seville, Spain; [Leo, E.] Hosp Univ Virgen Rocio, Gastroenterol, Seville, Spain; [Garcia, M. J.] Hosp Univ Marques Valdecilla IDIVAL, Gastroenterol, Santander, Spain; [Bertoletti, F.] Hosp Santa Creu & Sant Pau, Gastroenterol, Barcelona, Spain; [Alejandro, M.] Hosp Univ & Politecn La Fe, Gastroenterol, Valencia, Spain; [Suris, G.] Hosp Univ Bellvitge, Gastroenterol, Barcelona, Spain; [Casis, B.] Hosp Univ 12 Octubre, Gastroenterol, Madrid, Spain; [Ferreiro-Iglesias, R.] Hosp Clin Univ Santiago, Gastroenterol, Santiago De Compostela, Spain; [Baston, I.] Hosp Clin Univ Santiago, Gastroenterol, Santiago De Compostela, Spain; [Barreiro-de Acosta, M.] Hosp Clin Univ Santiago, Gastroenterol, Santiago De Compostela, Spain; [Calafat, M.] Hosp Badalona Germans Trias & Pujol, Gastroenterol, Badalona, Spain; [Jimenez, I.] Hosp Univ Galdakao, Gastroenterol, Bilbao, Spain; [Rodriguez-Lago, I.] Hosp Univ Galdakao, Gastroenterol, Bilbao, Spain; [Miranda-Bautista, J.] Hosp Univ Gregorio Maranon, Gastroenterol, Madrid, Spain; [Lamuela, L. J.] Hosp Univ Miguel Servet, Gastroenterol, Zaragoza, Spain; [Fajardo, I.] Hosp Univ Mutua Terrassa, Gastroenterol, Barcelona, Spain; [Torrealba, L.] Hosp Univ Doctor Josep Trueta, Gastroenterol, Girona, Spain; [Najera, R.] Hosp Univ Rio Hortega, Gastroenterol, Valladolid, Spain; [Saiz, R. M.] Hosp Univ Burgos, Gastroenterol, Burgos, Spain; [Gonzalez, I.] Hosp Univ Puerta Hierro Majadahonda, Gastroenterol, Madrid, Spain; [Vicuna, N.] Complejo Hosp Navarra, Gastroenterol, Pamplona, Spain; [Garcia-Morales, N.] Hosp Alvaro Cunqueiro, Gastroenterol, Vigo, Spain; [Gutierrez, A.] Hosp Gen Univ Alicante, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Inst Invest Sanitaria & Biomed Alicante ISABIAL, Gastroenterol, Alicante, Spain; [Lopez-Garcia, A.] Hosp Mar, Gastroenterol, Barcelona, Spain; [Benitez, J. N.] Hosp Univ Reina Sofia, Gastroenterol, Cordoba, Spain; [Rubin de Celix, C.] Hosp Univ La Princesa, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Inst Invest Sanitaria Princesa IIS IP, Gastroenterol, Madrid, Spain; [Tejido, C.] Complejo Hosp Univ Ourense, Gastroenterol, Orense, Spain; [Brunet, E.] Hosp Univ Parc Tauli, Gastroenterol, Sabadell, Spain; [Baltar, R.] Hosp Univ Alava, Gastroenterol, Alava, Spain; [Huguet, J. M.] Hosp Gen Univ Valencia, Gastroenterol, Valencia, Spain; [Hermida, B.] Hosp Univ Cabuenes, Gastroenterol, Gijon, Spain; [Caballero-Mateos, A.] Hosp Santa Ana Motril, Gastroenterol, Granada, Spain; [Sanchez-Guillen, L.] Hosp Gen Univ Elche, Colorrectal Surg, Alicante, Spain; [Bouhmidi, A.] Hosp Santa Barbara, Gastroenterol, Puertollano, Spain; [Pajares, B.] Hosp Univ Infanta Sofia, Gastroenterol, San Sebastian De Reyes, SpainItem Broadband 2 × 2 multimode interference coupler for mid-infrared wavelengths.(2021) Stirling, Callum J; Halir, Robert; Sánchez-Postigo, Alejandro; Qu, Zhibo; Reynolds, Jamie D; Penadés, Jordi Soler; Senthil Murugan, Ganapathy; Ortega-Moñux, Alejandro; Wangüemert-Pérez, J Gonzalo; Molina-Fernández, Íñigo; Mashanovich, Goran Z; Nedeljkovic, MilosBeam splitters are core components of photonic integrated circuits and are often implemented with multimode interference couplers. While these devices offer high performance, their operational bandwidth is still restrictive for sensing applications in the mid-infrared wavelength range. Here we experimentally demonstrate a subwavelength-structured 2×2 multimode interference coupler with high performance in the 3.1-3.7µm range, doubling the bandwidth of a conventional device.Item Suspended silicon mid-infrared waveguide devices with subwavelength grating metamaterial cladding.(2016) Penades, J Soler; Ortega-Moñux, A; Nedeljkovic, M; Wangüemert-Pérez, J G; Halir, R; Khokhar, A Z; Alonso-Ramos, C; Qu, Z; Molina-Fernández, I; Cheben, P; Mashanovich, G ZWe present several fundamental photonic building blocks based on suspended silicon waveguides supported by a lateral cladding comprising subwavelength grating metamaterial. We discuss the design, fabrication, and characterization of waveguide bends, multimode interference devices and Mach-Zehnder interferometers for the 3715 - 3800 nm wavelength range, demonstrated for the first time in this platform. The waveguide propagation loss of 0.82 dB/cm is reported, some of the lowest loss yet achieved in silicon waveguides for this wavelength range. These results establish a direct path to ultimately extending the operational wavelength range of silicon wire waveguides to the entire transparency window of silicon.Item Single-etch subwavelength engineered fiber-chip grating couplers for 1.3 µm datacom wavelength band.(2016) Benedikovic, Daniel; Alonso-Ramos, Carlos; Cheben, Pavel; Schmid, Jens H; Wang, Shurui; Halir, Robert; Ortega-Moñux, Alejandro; Xu, Dan-Xia; Vivien, Laurent; Lapointe, Jean; Janz, Siegfried; Dado, MilanWe report, for the first time, on the design and experimental demonstration of fiber-chip surface grating couplers based on subwavelength grating engineered nanostructure operating in the low fiber chromatic dispersion window (around 1.3 μm wavelengths), which is of great interest for short-reach data communication applications. Our coupler designs meet the minimum feature size requirements of large-volume deep-ultraviolet stepper lithography processes. The fiber-chip couplers are implemented in a standard 220-nm-thick silicon-on-insulator (SOI) platform and are fabricated by using a single etch process. Several types of couplers are presented, specifically the uniform, the apodized, and the focusing designs. The measured peak coupling efficiency is -2.5 dB (56%) near the central wavelength of 1.3 μm. In addition, by utilizing the technique of the backside substrate metallization underneath the grating couplers, the coupling efficiency of up to -0.5 dB (89%) is predicted by Finite Difference Time Domain (FDTD) calculations.Item Pelvic post-traumatic asymmetry: Assessment and sequenced treatment.(2018-05-21) Cano-Luís, Pedro; Giráldez-Sánchez, Miguel Ángel; Andrés-Cano, PabloThe most common cause of post-traumatic pelvic asymmetry is, by far, initial nonoperative treatment.Open reduction and internal fixation of unstable pelvic fractures are recommended to avoid pelvic nonunion or subsequent structural deformities.The most common symptom is pelvic pain. Pelvic instability is another symptom, as well as persistent urogenital problems and neurological sequelae.Preoperative evaluation of these patients requires careful clinical and functional assessment, in addition to a complete radiological study.Surgical treatment of pelvic fracture nonunions is technically demanding and has potentially serious complications.We have developed a new classification that modifies and completes Mears and Velyvis's classification in which we highlight two types of post-traumatic sequelae with different clinical conditions and whose basic differentiating element is whether pelvic deformity is present or not. Based on this classification, we have established our strategy of surgical treatment. Cite this article: EFORT Open Rev 2018;3 DOI: 10.1302/2058-5241.3.170069.Item Clinically apparent adverse reactions to intra-wound vancomycin powder in early onset scoliosis are rare.(2017) DeFrancesco, C J; Flynn, J M; Smith, J T; Luhmann, S J; Sawyer, J R; Glotzbecker, M; Pahys, J; Garg, S; Vitale, M; Farrington, D M; Sturm, P; Children’s Spine Study GroupSpine surgeons have increasingly used intraoperative application of topical vancomycin powder (TVP) to prevent surgical site infections (SSIs). The goals of this study were to define the rate of pharmacological adverse reaction to TVP in young patients undergoing posterior spinal surgery and to summarise institutional variation in TVP dosing. This retrospective observational study included ten spine centres in the United States and one in Europe. Patients with early onset scoliosis who underwent posterior spine surgery were eligible for inclusion. Age, weight, TVP dose and surgery type were recorded. Surgeries where patient age was > 12 years were excluded. Pharmacological adverse reactions were defined as clinical instances of Red Man Syndrome, rash, nephrotoxicity, proteinuria, hepatotoxicity or ototoxicity. The rate of pharmacological adverse reaction to TVP was calculated. Dosing practices were summarised. Patient age was in the range of seven months to 12 years (median ten years). Of 1398 observations, there was one possible pharmacological adverse reaction. This was in a ten-year-old, 20.4-kg female patient with neuromuscular sco-liosis undergoing growing rod implantation. She was dosed with 1500 mg of TVP and immediately developed a transient rash without systemic symptoms. This abated over minutes without any medical intervention. There were no other adverse reactions in the sample. The population rate of pharmacological adverse reaction was 0.072% (95% confidence interval 0 to 0.4). Significant variability in dosing practices existed between centres. Pharmacological adverse reactions to TVP are rare. Future work may establish evidence-based guidelines for TVP dosing based on patient weight and other variables.Item Cardiovascular impact of COVID-19 with a focus on children: A systematic review.(2020) Rodriguez-Gonzalez, Moises; Castellano-Martinez, Ana; Cascales-Poyatos, Helena Maria; Perez-Reviriego, Alvaro AntonioSince the beginning of the pandemic, coronavirus disease-2019 (COVID-19) in children has shown milder cases and a better prognosis than adults. Although the respiratory tract is the primary target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), cardiovascular involvement is emerging as one of the most significant and life-threatening complications of SARS-CoV-2 infection in adults. To summarize the current knowledge about the potential cardiovascular involvement in pediatric COVID-19 in order to give a perspective on how to take care of them during the current pandemic emergency. Multiple searches in MEDLINE, PubMed were performed using the search terms "COVID-19" or "SARS-CoV-2" were used in combination with "myocardial injury" or "arrhythmia" or "cardiovascular involvement" or "heart disease" or "congenital heart disease" or "pulmonary hypertension" or "long QT" or "cardiomyopathies" or "channelopathies" or "Multisystem inflammatory system" or "PMIS" or "MIS-C" or "Pediatric multisystem inflammatory syndrome" or "myocarditis" or "thromboembolism to identify articles published in English language from January 1st, 2020 until July 31st, 2020. The websites of World Health Organization, Centers for Disease control and Prevention, and the Johns Hopkins Coronavirus Resource Center were reviewed to provide up to date numbers and infection control recommendations. Reference lists from the articles were reviewed to identify additional pertinent articles. Retrieved manuscripts concerning the subject were reviewed by the authors, and the data were extracted using a standardized collection tool. Data were subsequently analyzed with descriptive statistics. For Pediatric multisystemic inflammatory syndrome temporally associated with COVID-19 (PMIS), multiple meta-analyses were conducted to summarize the pooled mean proportion of different cardiovascular variables in this population in pseudo-cohorts of observed patients. A total of 193 articles were included. Most publications used in this review were single case reports, small case series, and observational small-sized studies or literature reviews. The meta-analysis of 16 studies with size > 10 patients and with complete data about cardiovascular involvement in children with PMIS showed that PMIS affects mostly previously healthy school-aged children and adolescents presenting with Kawasaki disease-like features and multiple organ failure with a focus on the heart, accounting for most cases of pediatric COVID-19 mortality. They frequently presented cardiogenic shock (53%), ECG alterations (27%), myocardial dysfunction (52%), and coronary artery dilation (15%). Most cases required PICU admission (75%) and inotropic support (57%), with the rare need for extracorporeal membrane oxygenation (4%). Almost all of these children wholly recovered in a few days, although rare deaths have been reported (2%). Out of PMIS cases we identified 10 articles reporting sporadic cases of myocarditis, pulmonary hypertension and cardiac arrythmias in previously healthy children. We also found another 10 studies reporting patients with pre-existing heart diseases. Most cases consisted in children with severe COVID-19 infection with full recovery after intensive care support, but cases of death were also identified. The management of different cardiac conditions are provided based on current guidelines and expert panel recommendations. There is still scarce data about the role of cardiovascular involvement in COVID-19 in children. Based on our review, children (previously healthy or with pre-existing heart disease) with acute COVID-19 requiring hospital admission should undergo a cardiac workup and close cardiovascular monitoring to identify and treat timely life-threatening cardiac complications.