Publication: Genetic Susceptibility in Head and Neck Squamous Cell Carcinoma in a Spanish Population.
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Identifiers
Date
2019-04-07
Authors
Fernandez-Mateos, Javier
Seijas-Tamayo, Raquel
Adansa-Klain, Juan Carlos
Pastor-Borgoñon, Miguel
Perez-Ruiz, Elisabeth
Mesia, Ricard
Del-Barco, Elvira
Salvador-Coloma, Carmen
Rueda-Dominguez, Antonio
Caballero-Daroqui, Javier
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Despite classical environmental risk factors like tobacco, alcohol or viral infection, not all individuals develop head and neck cancer. Therefore, identification of the genetic susceptibility produced by single nucleotide polymorphisms (SNPs) is an important task. A total of 296 human papillomavirus negative head and neck cancer (HNC) patients (126 laryngeal, 100 pharyngeal and 70 oral cavity) were included in the study, involving 29 candidate SNPs in genes within important carcinogenic pathways (oncogenesis and tumour suppression, DNA repair, inflammation, oxidation and apoptosis). Genotyping was performed using TaqMan probes or restriction fragment length assays in peripheral blood DNA. In addition, 259 paired controls were also evaluated with the same risk factors for each specific location. Nine SNPs in DNA repair (ERCC1 rs11615, ERCC2 rs13181), inflammatory (IL2 rs2069762, IL6 rs1800795), oxidative (NFE2L2 rs13035806 and rs2706110) and apoptotic genes (TP53 rs1042522, MDM2 rs2279744, BCL2 rs2279115) were differently associated with HNSCC susceptibility by location. Some of these SNPs were not described before in this tumour type. In conclusion, we describe several SNPs associated with HNC in a Spanish population.
Description
MeSH Terms
DeCS Terms
Polimorfismo de Nucleótido Simple
Neoplasias de Cabeza y Cuello
Selección del Sitio de Tratamiento de Residuos
Reparación del ADN
Virus del Papiloma Humano
Predisposición Genética a la Enfermedad
Neoplasias de Cabeza y Cuello
Selección del Sitio de Tratamiento de Residuos
Reparación del ADN
Virus del Papiloma Humano
Predisposición Genética a la Enfermedad
CIE Terms
Keywords
Spanish population, Head and neck cancer, Single nucleotide polymorphisms
Citation
Fernández-Mateos J, Seijas-Tamayo R, Adansa Klain JC, Pastor Borgoñón M, Pérez-Ruiz E, Mesía R, et al. Genetic Susceptibility in Head and Neck Squamous Cell Carcinoma in a Spanish Population. Cancers (Basel). 2019 Apr 7;11(4):493