RT Journal Article
T1 Genetic Susceptibility in Head and Neck Squamous Cell Carcinoma in a Spanish Population.
A1 Fernandez-Mateos, Javier
A1 Seijas-Tamayo, Raquel
A1 Adansa-Klain, Juan Carlos
A1 Pastor-Borgoñon, Miguel
A1 Perez-Ruiz, Elisabeth
A1 Mesia, Ricard
A1 Del-Barco, Elvira
A1 Salvador-Coloma, Carmen
A1 Rueda-Dominguez, Antonio
A1 Caballero-Daroqui, Javier
A1 Fernandez-Ruiz, Encarnacion
A1 Ocana, Alberto
A1 Gonzalez-Sarmiento, Rogelio
A1 Cruz-Hernandez, Juan Jesus
K1 Spanish population
K1 Head and neck cancer
K1 Single nucleotide polymorphisms
AB Despite classical environmental risk factors like tobacco, alcohol or viral infection, not all individuals develop head and neck cancer. Therefore, identification of the genetic susceptibility produced by single nucleotide polymorphisms (SNPs) is an important task. A total of 296 human papillomavirus negative head and neck cancer (HNC) patients (126 laryngeal, 100 pharyngeal and 70 oral cavity) were included in the study, involving 29 candidate SNPs in genes within important carcinogenic pathways (oncogenesis and tumour suppression, DNA repair, inflammation, oxidation and apoptosis). Genotyping was performed using TaqMan probes or restriction fragment length assays in peripheral blood DNA. In addition, 259 paired controls were also evaluated with the same risk factors for each specific location. Nine SNPs in DNA repair (ERCC1 rs11615, ERCC2 rs13181), inflammatory (IL2 rs2069762, IL6 rs1800795), oxidative (NFE2L2 rs13035806 and rs2706110) and apoptotic genes (TP53 rs1042522, MDM2 rs2279744, BCL2 rs2279115) were differently associated with HNSCC susceptibility by location. Some of these SNPs were not described before in this tumour type. In conclusion, we describe several SNPs associated with HNC in a Spanish population.
PB MDPI
SN 2072-6694
YR 2019
FD 2019-04-07
LK http://hdl.handle.net/10668/13798
UL http://hdl.handle.net/10668/13798
LA en
NO Fernández-Mateos J, Seijas-Tamayo R, Adansa Klain JC, Pastor Borgoñón M, Pérez-Ruiz E, Mesía R, et al. Genetic Susceptibility in Head and Neck Squamous Cell Carcinoma in a Spanish Population. Cancers (Basel). 2019 Apr 7;11(4):493
NO “Instituto de Salud Carlos III” (Spanish Ministry of Economy and Competitiveness)
DS RISalud
RD Apr 7, 2025