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Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

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2019-03-28

Authors

Sanikini, Harinakshi
Muller, David C
Sophiea, Marisa
Rinaldi, Sabina
Agudo, Antonio
Duell, Eric J
Weiderpass, Elisabete
Overvad, Kim
Tjønneland, Anne
Halkjaer, Jytte

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John Wiley & Sons, Inc
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Abstract

Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models. During a mean follow-up of 14 years, 220 esophageal adenocarcinomas (EA), 195 esophageal squamous cell carcinomas, 243 gastric cardia (GC) and 373 gastric noncardia (GNC) cancers were diagnosed. Body mass index (BMI) was associated with EA in men (BMI ≥30 vs. 18.5-25 kg/m2 : HR = 1.94, 95% CI: 1.25-3.03) and women (HR = 2.66, 95% CI: 1.15-6.19); however, adjustment for waist-to-hip ratio (WHR) attenuated these associations. After mutual adjustment for BMI and HC, respectively, WHR and waist circumference (WC) were associated with EA in men (HR = 3.47, 95% CI: 1.99-6.06 for WHR >0.96 vs. 0.96 vs. 98 vs. 0.82 vs. 84 vs. 2 vs. 0) and age at first pregnancy and GNC (HR = 0.54, 95% CI: 0.32-0.91; >26 vs. 26 vs.

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MeSH Terms

Anthropometry
Body Fat Distribution
Cohort Studies
Esophageal Neoplasms
Europe
Female
Humans
Male
Middle Aged
Proportional Hazards Models
Prospective Studies
Reproductive History
Risk Factors
Stomach Neoplasms

DeCS Terms

Antropometría
Distribución de la grasa corporal
Historia reproductiva
Femenino
Factores de riesgo
Humanos
Historia reproductiva
Persona de mediana edad
Neoplasias gástricas
Neoplasias esofágicas
Modelos de riesgos proporcionales

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Keywords

cancer, esophageal, gastric, hormones, obesity, reproductive

Citation

Sanikini H, Muller DC, Sophiea M, Rinaldi S, Agudo A, Duell EJ, et al. Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Int J Cancer. 2020 Feb 15;146(4):929-942.