Publication:
Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis

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Date

2021-04-10

Authors

Martin-Perez, Antonio Jose
Fernández-González, María
Postigo-Martin, Paula
Sampedro Pilegaard, Marc
Fernández-Lao, Carolina
Castro-Martín, Eduardo
Martín-Martín, Lydia
Lozano-Lozano, Mario

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MDPI
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Abstract

There is no systematic review that has identified existing studies evaluating the pharmacological and non-pharmacological intervention for pain management in patients with bone metastasis. To fill this gap in the literature, this systematic review with meta-analysis aims to evaluate the effectiveness of different antalgic therapies (pharmacological and non-pharmacological) in the improvement of pain of these patients. To this end, this protocol has been written according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) and registered in PROSPERO (CRD42020135762). A systematic search will be carried out in four international databases: Medline (Via PubMed), Web of Science, Cochrane Library and SCOPUS, to select the randomized controlled clinical trials. The Risk of Bias Tool developed by Cochrane will be used to assess the risk of bias and the quality of the identified studies. A narrative synthesis will be used to describe and compare the studies, and after the data extraction, random effects model and a subgroup analyses will be performed according to the type of intervention, if possible. This protocol aims to generate a systematic review that compiles and synthesizes the best and most recent evidence on the treatment of pain derived from vertebral metastasis.

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Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Pain Management
Medical Subject Headings::Information Science::Information Science::Information Storage and Retrieval::Databases as Topic::Databases, Bibliographic::PubMed
Medical Subject Headings::Information Science::Information Science::Information Services::Bibliography as Topic::Bibliometrics
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Pain
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Meta-Analysis as Topic

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Keywords

Systematic review, Neoplasm metastasis, Bone and bones, Spine, Pain, Protocol, Revisión sistemática, Metástasis de la neoplasia, Huesos, Columna vertebral, Dolor

Citation

Martin-Perez AJ, Fernández-González M, Postigo-Martin P, Sampedro Pilegaard M, Fernández-Lao C, Castro-Martín E, et al. Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2021 Apr 10;18(8):3991