RT Journal Article
T1 Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis
A1 Martin-Perez, Antonio Jose
A1 Fernández-González, María
A1 Postigo-Martin, Paula
A1 Sampedro Pilegaard, Marc
A1 Fernández-Lao, Carolina
A1 Castro-Martín, Eduardo
A1 Martín-Martín, Lydia
A1 Lozano-Lozano, Mario
K1 Systematic review
K1 Neoplasm metastasis
K1 Bone and bones
K1 Spine
K1 Pain
K1 Protocol
K1 Revisión sistemática
K1 Metástasis de la neoplasia
K1 Huesos
K1 Columna vertebral
K1 Dolor
AB There is no systematic review that has identified existing studies evaluating the pharmacological and non-pharmacological intervention for pain management in patients with bone metastasis. To fill this gap in the literature, this systematic review with meta-analysis aims to evaluate the effectiveness of different antalgic therapies (pharmacological and non-pharmacological) in the improvement of pain of these patients. To this end, this protocol has been written according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) and registered in PROSPERO (CRD42020135762). A systematic search will be carried out in four international databases: Medline (Via PubMed), Web of Science, Cochrane Library and SCOPUS, to select the randomized controlled clinical trials. The Risk of Bias Tool developed by Cochrane will be used to assess the risk of bias and the quality of the identified studies. A narrative synthesis will be used to describe and compare the studies, and after the data extraction, random effects model and a subgroup analyses will be performed according to the type of intervention, if possible. This protocol aims to generate a systematic review that compiles and synthesizes the best and most recent evidence on the treatment of pain derived from vertebral metastasis.
PB MDPI
SN 1661-7827
YR 2021
FD 2021-04-10
LK http://hdl.handle.net/10668/4282
UL http://hdl.handle.net/10668/4282
LA en
NO Martin-Perez AJ, Fernández-González M, Postigo-Martin P, Sampedro Pilegaard M, Fernández-Lao C, Castro-Martín E, et al. Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2021 Apr 10;18(8):3991
DS RISalud
RD Apr 7, 2025